ArticleOral microbiology and immunology2009
Proteomic analysis of endodontic infections by liquid chromatography-tandem mass spectrometry.
Article in Oral microbiology and immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Proteomic profiling of pulpal and periapical diseases: a systematic review.Frontiers in dental medicine · 2026Pooled it
- A polymicrobial perspective into the ecological role of Enterococcus faecalis in dental root canal infections.NPJ biofilms and microbiomes · 2025Review
- Article
- Next steps in studying host-microbiome interactions in apical periodontitis.Frontiers in oral health · 2023Article
- Antibiotic indication in endodontics by Colombian dentists with different levels of training: a survey.Acta odontologica latinoamericana : AOL · 2022Article
- Microbiological Aspects of Root Canal Infections and Disinfection Strategies: An Update Review on the Current Knowledge and Challenges.Frontiers in oral health · 2021Review
- Biochemical characterization of extracellular polymeric substances from endodontic biofilms.PloS one · 2018Article
- Metaproteome analysis of endodontic infections in association with different clinical conditions.PloS one · 2013Article
- Photodynamic and antibiotic therapy impair the pathogenesis of Enterococcus faecium in a whole animal insect model.PloS one · 2013Article
- Insights into the virulence of oral biofilms: discoveries from proteomics.Expert review of proteomics · 2012Review
- Antibiotic resistance in primary and persistent endodontic infections.Journal of endodontics · 2011Article
- Mass spectrometric analysis of multiple pertussis toxins and toxoids.Journal of biomedicine & biotechnology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
introductionEndodontic infections are very prevalent and have a polymicrobial etiology characterized by complex interrelationships between endodontic microorganisms and the host defenses. Proteomic analysis of endodontic infections can provide global insights into the invasion, pathogenicity mechanisms, and multifactorial interactions existing between root canal bacteria and the host in the initiation and progression of apical periodontitis. The purpose of this study was to apply proteomic techniques such as liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the identification of proteins of bacterial origin present in endodontic infections.
methodsEndodontic specimens were aseptically obtained from seven patients with root canal infections. Protein mixtures were subjected to tryptic in-solution digestion and analysed by reverse-phase nano-LC-MS/MS followed by a database search.
resultsProteins, mainly of cell wall or membrane origin, from endodontic bacteria especially Enterococcus faecalis, Enterococcus faecium, Porphyromonas gingivalis, Fusobacterium nucleatum, and Treponema denticola were identified from all the samples tested. Identified proteins included adhesins, autolysins, proteases, virulence factors, and antibiotic-resistance proteins.
conclusionsLC-MS/MS offers a sensitive analytical platform to study the disease processes in the root canal environment. The array of proteins expressed in endodontic infections reflects the complex microbial presence and highlights the bacterial species involved in the inflammatory process.
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