ArticleThe Journal of infectious diseases2009
Mechanism of human natural killer cell activation by Haemophilus ducreyi.
Article in The Journal of infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Molecular pathogenesis ofMicrobiology and molecular biology reviews : MMBR · 2025Review
- Article
- Article
- Interactions of the Skin PathogenFrontiers in immunology · 2020Review
- Article
- Increased level and interferon-γ production of circulating natural killer cells in patients with scrub typhus.PLoS neglected tropical diseases · 2017Article
- Host Polymorphisms in TLR9 and IL10 Are Associated With the Outcomes of Experimental Haemophilus ducreyi Infection in Human Volunteers.The Journal of infectious diseases · 2016Article
- The Human Skin Microbiome Associates with the Outcome of and Is Influenced by Bacterial Infection.mBio · 2015Article
- Haemophilus ducreyi infection induces activation of the NLRP3 inflammasome in nonpolarized but not in polarized human macrophages.Infection and immunity · 2013Article
- Haemophilus ducreyi-induced interleukin-10 promotes a mixed M1 and M2 activation program in human macrophages.Infection and immunity · 2012Article
- Immune evasion and recognition of the syphilis spirochete in blood and skin of secondary syphilis patients: two immunologically distinct compartments.PLoS neglected tropical diseases · 2012Article
- Haemophilus ducreyi lipooligosaccharides induce expression of the immunosuppressive enzyme indoleamine 2,3-dioxygenase via type I interferons and tumor necrosis factor alpha in human dendritic cells.Infection and immunity · 2011Article
- A distinct subset of human NK cells expressing HLA-DR expand in response to IL-2 and can aid immune responses to BCG.European journal of immunology · 2011Article
- Deletion of mtrC in Haemophilus ducreyi increases sensitivity to human antimicrobial peptides and activates the CpxRA regulon.Infection and immunity · 2011Article
- Systemic effector and regulatory immune responses to chlamydial antigens in trachomatous trichiasis.Frontiers in microbiology · 2011Article
- Role played by CD4+FOXP3+ regulatory T Cells in suppression of host responses to Haemophilus ducreyi during experimental infection of human volunteers.The Journal of infectious diseases · 2010Article
- Host-pathogen interplay of Haemophilus ducreyi.Current opinion in infectious diseases · 2010Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The role of natural killer (NK) cells in the host response to Haemophilus ducreyi infection is unclear. In pustules obtained from infected human volunteers, there was an enrichment of CD56bright NK cells bearing the activation markers CD69 and HLA-DR, compared with peripheral blood. To study the mechanism by which H. ducreyi activated NK cells, we used peripheral blood mononuclear cells from uninfected volunteers. H. ducreyi activated NK cells only in the presence of antigen-presenting cells. H. ducreyi-infected monocytes and monocyte-derived macrophages activated NK cells in a contact- and interleukin-18 (IL-18)-dependent manner, whereas monocyte-derived dendritic cells induced NK activation through soluble IL-12. More lesional NK cells than peripheral blood NK cells produced IFN-gamma in response to IL-12 and IL-18. We conclude that NK cells are recruited to experimental lesions and likely are activated by infected macrophages and dendritic cells. IFN-gamma produced by lesional NK cells may facilitate phagocytosis of H. ducreyi.
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