Evidence map›Paper›PMID 19572558›Full record

ArticleAnalytical chemistry2009

Simultaneous collision induced dissociation of the charge reduced parent ion during electron capture dissociation.

Jared M Bushey, Takashi Baba, Gary L Glish

Abstract read
In one paragraph

Article in Analytical chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jared M BusheyDepartment of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Takashi Baba
Gary L Glish

Funding

Instrument for Determining Intramolecular InteractionsR21RR020207 · NCRR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GLISH, GARY L · 2006 to 2007
$322k
NCRR NIH HHS 5R21RR020207NCRR NIH HHS R21 RR020207
6 · The paper itself

Abstract

A method of performing collision induced dissociation (CID) on the charge-reduced parent ion as it is formed during electron capture dissociation (ECD), called ECD+CID, is described. In ECD+CID, the charge-reduced parent ion is selectively activated using resonant excitation and collisions with the helium bath gas inside a linear quadrupole ion trap ECD device (ECD(LIT)). It has been observed that ECD+CID can improve the sequence coverage for beta-endorphin over performing ECD alone (i.e., from 72 to 97%). Perhaps just as important, ECD+CID can be used to reduce the extent of multiple electron capture events observed when performing ECD in the ECD(LIT). Consequently, the abundance of mass-to-charge ratios corresponding to ECD product ions that contain neutralized protons is decreased, simplifying the interpretation of the product ion spectrum.

Indexed as

ElectronsIonsbeta-EndorphinHeliumMelittenProtonsSpectrometry, Mass, Electrospray IonizationTandem Mass Spectrometrybeta-EndorphinHeliumIonsMelittenProtons

Identifiers

PMID19572558
PMCPMC3141179

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.