ArticleHuman mutation2009
Measurement of admixture proportions and description of admixture structure in different U.S. populations.
Article in Human mutation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed.
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- Levels of Genital Tract Defensins and Cytokines Differ between HIV-Uninfected US and African Women.American journal of reproductive immunology (New York, N.Y. : 1989) · 2015Trial
- GRIK1 genotype and daily expectations of alcohol's positive effects moderate the reduction of heavy drinking by topiramate.Experimental and clinical psychopharmacology · 2014Trial
- GRIK1 genotype moderates topiramate's effects on daily drinking level, expectations of alcohol's positive effects and desire to drink.The international journal of neuropsychopharmacology · 2014Trial
- African ancestry, early life exposures, and respiratory morbidity in early childhood.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2012Trial
- Ancestry-informative markers and variants of uncertain significance on hereditary cancer panels.Frontiers in oncology · 2026Article
- Conservation genetic evaluation of Juniperus communis sensu lato in Slovakia.Scientific reports · 2025Article
- Development of the PICCOTEAM Reference Case for Economic Evaluation of Precision Medicine.International journal of health policy and management · 2025Article
- Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium.HGG advances · 2022Article
- Local ancestry at APOE modifies Alzheimer's disease risk in Caribbean Hispanics.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019Article
- Next-generation sequencing reveals new information about HLA allele and haplotype diversity in a large European American population.Human immunology · 2019Article
- Genetic Ancestry Analysis Reveals Misclassification of Commonly Used Cancer Cell Lines.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Article
- Circulating Interleukin-6 concentration covaries inversely with self-reported sleep duration as a function of polymorphic variation in the glucocorticoid receptor.Brain, behavior, and immunity · 2019Article
- Prevention of Early Substance Use Mediates, and Variation at SLC6A4 Moderates, SAAF Intervention Effects on OXTR Methylation.Prevention science : the official journal of the Society for Prevention Research · 2018Article
- Long-distance dispersal suppresses introgression of local alleles during range expansions.Heredity · 2017Article
- The prevalence and distribution of the amyloidogenic transthyretin (TTR) V122I allele in Africa.Molecular genetics & genomic medicine · 2016Article
- Selecting SNPs informative for African, American Indian and European Ancestry: application to the Family Investigation of Nephropathy and Diabetes (FIND).BMC genomics · 2016Article
- Economic hardship and biological weathering: The epigenetics of aging in a U.S. sample of black women.Social science & medicine (1982) · 2016Article
- Circadian rhythm phase shifts and endogenous free-running circadian period differ between African-Americans and European-Americans.Scientific reports · 2015Article
- The genetic ancestry of African Americans, Latinos, and European Americans across the United States.American journal of human genetics · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Variation in individual admixture proportions leads to heterogeneity within populations. Though novel methods and marker panels have been developed to quantify individual admixture, empirical data describing individual admixture distributions are limited. We investigated variation in individual admixture in four U.S. populations (European American [EA], African American [AA], Hispanics from Connecticut [East Coast, or EC], and Hispanics from California [West Coast, or WC]) assuming three-way intermixture among Europeans, Africans, and Indigenous Americans. Admixture estimates were inferred using a panel of 36 microsatellites and one SNP, which have significant allele frequency differences between ancestral populations, and by using both a maximum likelihood (ML)-based method and a Bayesian method implemented in the program STRUCTURE. Simulation studies showed that estimates obtained with this marker panel are within 96% of expected values. EAs had the lowest non-European admixture with both methods, but showed greater homogeneity with STRUCTURE than with ML. All other samples showed a high degree of variation in admixture estimates with both methods, were highly concordant, and showed evidence of admixture stratification. With both methods, AA subjects had on average, 16% European and <10% Indigenous American admixture. EC Hispanics had higher mean African admixture and the WC Hispanics had higher mean Indigenous American admixture, possibly reflecting their different continental origins.
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