ArticleVeterinary research communications2009
Pharmacokinetic studies of levofloxacin after oral administration in healthy and febrile cow calves.
Article in Veterinary research communications, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 9 citations in OpenAlex.
- The effects of Mannheimia haemolytica and albendazole on marbofloxacin pharmacokinetics in lambs.Tropical animal health and production · 2019Article
- Pharmacokinetics of ceftiofur in healthy and lipopolysaccharide-induced endotoxemic newborn calves treated with single and combined therapy.The Journal of veterinary medical science · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present experiment was designed to study the pharmacokinetics of levofloxacin in six healthy cross bred female cow calves (4 to 6 months age) weighing between 40 to 80 kg. Plasma from blood was separated by centrifugation at 10,000 rpm. Quantitative estimation of levofloxacin was done by UV-VIS spectrophotometer at 286 nm. The mean maximum plasma concentration (Cp(max)) of levofloxacin in febrile calves (5.28±0.32 μg/ml) did not differ significantly as compared with healthy calves (4.50±0.22 μg/ml) after single dose (20 mg/kg) oral administration. The mean therapeutic plasma concentration (Cp(ther)) of levofloxacin was maintained for longer period in febrile calves (10 h) as compared to healthy calves ( 8 h). The mean maximum urine concentration (Cu(max)) in febrile (40.86±2.19 μg/ml) also did not differ significantly as compared with healthy calves (39.38±2.43 μg/ml). No significant difference in various pharmacokinetic parameters of plasma was observed in healthy calves ( β=0.23±0.01/h ; t½β=3.00±0.17 h and MRT=4.66±0.14 h ) and febrile calves ( β=0.23±0.01/ h; t½β=3.05±0.16 h and MRT=5.04±0.14 h). The mean value of β, and t½β calculated in urine also did not differ between healthy and febrile calves. However, the value of MRT(3.79±0.07 h) and Cl(B) (1.65±0.09 ml/kg/min) calculated in urine of febrile calves significantly (p<0.05) differ to healthy calves (MRT=3.15±0.03 h;Cl(B)=2.09±0.13 ml/kg/min). Based on kinetic profile levofloxacin may be given orally at the dose rate of 1.49 mg/kg B.W.at 8 h intervals in febrile calves.
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