ArticleThe open virology journal2009
The evolution of viruses in multi-host fitness landscapes.
Article in The open virology journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 132 citations in OpenAlex.
- Standing HA phenotypic breadth shapes H5N1 cross-host potential.Research square · 2026Article
- Narrowed host ranges do not constrain future host range expansion in RNA phage Φ6.Journal of virology · 2026Article
- A single amino acid mutation in norovirus NS4 promotes viral spread.Journal of virology · 2026Article
- Ecological factors and genetic features are associated with ecological generalism in pathogenic tick-borne viruses.Nature communications · 2026Article
- Warming disrupts infection patterns and primarily acceleratesISME communications · 2026Article
- A data-driven sliding-window pairwise comparative approach for the estimation of transmission fitness of SARS-CoV-2 variants and construction of the evolution fitness landscape.Quantitative biology (Beijing, China) · 2025Article
- Global wastewater microbiome reveals core bacterial community and viral diversity with regional antibiotic resistance patterns.mSystems · 2025Article
- The importance of epistasis in the evolution of viral pathogens.Virus evolution · 2025Review
- Quantifying the strength of viral fitness trade-offs between hosts: a meta-analysis of pleiotropic fitness effects.Evolution letters · 2024Article
- The Evolution of Wisteria Vein Mosaic Virus: A Case Study Approach to Track the Emergence of New Potyvirus Threats.Pathogens (Basel, Switzerland) · 2024Article
- Review
- Competition-driven eco-evolutionary feedback reshapes bacteriophage lambda's fitness landscape and enables speciation.Nature communications · 2024Article
- A meta-analysis highlights the idiosyncratic nature of tradeoffs in laboratory models of virus evolution.Virus evolution · 2024Article
- Host-specific adaptation drove the coevolution of leek yellow stripe virus andMicrobiology spectrum · 2023Article
- Amphibian infection tolerance to chytridiomycosis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- In-depth study of tomato and weed viromes reveals undiscovered plant virus diversity in an agroecosystem.Microbiome · 2023Article
- Metagenomics reveals the structure ofVirus evolution · 2023Article
- Limited cross-species virus transmission in a spatially restricted coral reef fish community.Virus evolution · 2023Article
- Structural bioinformatics analysis of SARS-CoV-2 variants reveals higher hACE2 receptor binding affinity for Omicron B.1.1.529 spike RBD compared to wild type reference.Scientific reports · 2022Article
- Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Provided that generalist viruses will have access to potentially unlimited hosts, the question is why most viruses specialize in few hosts. It has been suggested that selection should favor specialists because there are tradeoffs limiting the fitness of generalists in any of the alternative hosts or because evolution proceeds faster with narrower niches. Here we review experiments showing that virus adaptation to a specific host is often coupled with fitness losses in alternative ones. In most instances, mutations beneficial in one host are detrimental in another. This antagonistic pleiotropy should limit the range of adaptation and promote the evolution of specialization. However, when hosts fluctuate in time or space, selective pressures are different and generalist viruses may evolve as well.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.