ArticleMucosal immunology2009
Suppression of Th1 and Th17, but not Th2, responses in a CD8(+) T cell-mediated model of oral tolerance.
Article in Mucosal immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- A novel defined TLR3 agonist as an effective vaccine adjuvant.Frontiers in immunology · 2023Article
- New Insights on CD8Frontiers in immunology · 2021Review
- Role of Regulatory Cells in Oral Tolerance.Allergy, asthma & immunology research · 2017Review
- Serum and mucosal antibody responses to inactivated polio vaccine after sublingual immunization using a thermoresponsive gel delivery system.Human vaccines & immunotherapeutics · 2014Article
- Mechanism of oral tolerance induction to therapeutic proteins.Advanced drug delivery reviews · 2013Review
- Mucosal immunology of food allergy.Current biology : CB · 2013Review
- Engineering antigens for in situ erythrocyte binding induces T-cell deletion.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Can we produce true tolerance in patients with food allergy?The Journal of allergy and clinical immunology · 2013Review
- Modulation of the effects of lung immune response on bone marrow by oral antigen exposure.BioMed research international · 2013Article
- Mucosal immunology of tolerance and allergy in the gastrointestinal tract.Immunologic research · 2012Review
- Phenotypical and functional analysis of intraepithelial lymphocytes from small intestine of mice in oral tolerance.Clinical & developmental immunology · 2012Article
- Gut-tropic T cells that express integrin α4β7 and CCR9 are required for induction of oral immune tolerance in mice.Gastroenterology · 2011Article
- B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance.Blood · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The role of CD8(+) T cells in oral tolerance remains unclear. To address this, we developed a model to induce CD8(+) Tregs by feeding the major histocompatibility complex class I immunodominant epitope of OVA, OVA((257-264)). OVA((257-264)) feeding induced tolerance similar to that observed in OVA protein-fed mice, capable of suppressing the production of Th1 and Th17 cytokines and inhibiting a Th1-driven delayed-type hypersensitivity response following immunization with whole OVA (wOVA) protein. OVA((257-264)) peptide-induced suppression could be transferred to naive mice with CD8(+) cells, but not CD8-depleted cells, isolated from mesenteric lymph nodes of peptide-fed mice. Interestingly, while capable of inhibiting Th1 and Th17 responses, OVA((257-264)) feeding could not suppress any feature of a Th2 inflammatory response, though OVA protein feeding could, suggesting that these cells function through a different mechanism than their CD4(+) counterparts generated in response to feeding with wOVA. Thus, CD8(+) T cells are functionally capable of mediating tolerance to Th1 and Th17 responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.