ArticleAlzheimer disease and associated disorders
Comparison of recruitment efforts targeted at primary care physicians versus the community at large for participation in Alzheimer disease clinical trials.
Article in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Trial
- Asthma and chronic obstructive pulmonary disease guideline implementation: lessons learned on recruitment of primary care physicians to a knowledge translation study.Canadian respiratory journalTrial
- Evaluating evidence-based recruitment strategies for Alzheimer's disease and related dementias clinical trial research: A literature review.The journal of prevention of Alzheimer's disease · 2026Review
- Best practices for recruitment in veterinary clinical trials.Frontiers in veterinary science · 2024Review
- Recruitment of a diverse research cohort in a large metropolitan area for dementia intervention studies.Contemporary clinical trials · 2022Article
- Diversifying Recruitment Registries: Considering Neighborhood Health Metrics.The journal of prevention of Alzheimer's disease · 2022Article
- Promoting successful participation of people living with Alzheimer's disease and related dementias in pain-related neuroimaging research studies.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- Modifiable Barriers for Recruitment and Retention of Older Adults Participants from Underrepresented Minorities in Alzheimer's Disease Research.Journal of Alzheimer's disease : JAD · 2021Review
- Race- and Sex-Based Disparities in Alzheimer's Disease Clinical Trial Enrollment in the United States and Canada: An Indigenous Perspective.Journal of Alzheimer's disease reports · 2020Review
- Community memory screening as a strategy for recruiting older adults into Alzheimer's disease research.Alzheimer's research & therapy · 2020Article
- Recruitment and retention of underrepresented populations in Alzheimer's disease research: A systematic review.Alzheimer's & dementia (New York, N. Y.) · 2019Review
- Patient Engagement: The Fundació ACE Framework for Improving Recruitment and Retention in Alzheimer's Disease Research.Journal of Alzheimer's disease : JAD · 2018Review
- Recruiting Community-Based Dementia Patients and Caregivers in a Nonpharmacologic Randomized Trial: What Works and How Much Does It Cost?Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2016Article
- Article
- A Multipronged, Adaptive Approach for the Recruitment of Diverse Community-Residing Elders with Memory Impairment: The MIND at Home Experience.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2015Article
- Obstacles and opportunities in Alzheimer's clinical trial recruitment.Health affairs (Project Hope) · 2014Article
- Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease.Acta neuropathologica · 2013Review
- Optimization of the inclusion of Alzheimer's disease patients in international multicenter randomized trials: results of a national survey conducted in memory research centers in france.Dementia and geriatric cognitive disorders extra · 2013Article
- Addressing the challenges to successful recruitment and retention in Alzheimer's disease clinical trials.Alzheimer's research & therapy · 2010Article
- The Effectiveness of Community-based Outreach Events for the Promotion of African American Research Participation.Alzheimer disease and associated disordersArticle
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Inefficient and delayed recruitment into clinical trials in Alzheimer disease are major obstacles impeding progress in the discovery of more effective therapeutic strategies to combat this disease. Despite widespread recognition of this problem, limited empirical data demonstrating the effectiveness of specific recruitment strategies are available to guide recruitment endeavors. This study was designed to evaluate the effectiveness of recruitment efforts targeting either the primary care health professionals (PCPs) or patients and families with a community grass-roots outreach event. The primary outcome measure was actual study recruitment and participation in the 4 months postintervention. No research subjects were recruited from the PCP intervention, whereas 69 subjects were recruited into clinical studies from the community grass-roots outreach event activity (0% vs. 28%, P<0.0001, Fisher exact test). Barriers to recruitment success in the PCP arm included a perception of perceived harm to subjects from research participation and fear of losing patients through clinical research participation. Our results suggest that outreach efforts directed at the potential study subject/caregiver are not only cost-effective but are able to easily accomplish the desired result of direct recruitment into clinical research studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.