ArticleJournal of vascular research2009
MT1-MMP-mediated cleavage of decorin in corneal angiogenesis.
Article in Journal of vascular research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
37 citing papers in PubMed, 64 citations in OpenAlex.
- Matrix Metalloproteinase 14 in Corneal Neovascularization.International journal of molecular sciences · 2026Review
- The Role of Decorin in the Ocular Surface: Structure, Function, and Therapeutic Potential.Proteoglycan research · 2025Article
- Target specification and therapeutic potential of extracellular vesicles for regulating corneal angiogenesis, lymphangiogenesis, and nerve repair.The ocular surface · 2024Review
- Novel regulatory roles of small leucine-rich proteoglycans in remodeling of the uterine cervix in pregnancy.Matrix biology : journal of the International Society for Matrix Biology · 2022Article
- Differential MMP-14 Targeting by Lumican-Derived Peptides Unraveled by In Silico Approach.Cancers · 2021Article
- Topical bevacizumab for the treatment of corneal vascularization in dogs: A case series.Veterinary ophthalmology · 2021Article
- The functional role of decorin in corneal neovascularization in vivo.Experimental eye research · 2021Article
- Relationship between increased serum & synovial fluid decorin levels & knee osteoarthritis.The Indian journal of medical research · 2021Article
- Neointimal Hyperplasia after Carotid Transection and Anastomosis Surgery is Associated with Degradation of Decorin and Platelet Derived Growth Factor Signaling.JVS-vascular science · 2021Article
- Glycosaminoglycan Modification of Decorin Depends on MMP14 Activity and Regulates Collagen Assembly.Cells · 2020Article
- Extracellular Matrix Composition and Remodeling: Current Perspectives on Secondary Palate Formation, Cleft Lip/Palate, and Palatal Reconstruction.Frontiers in cell and developmental biology · 2019Review
- Decorin is a pivotal effector in the extracellular matrix and tumour microenvironment.Oncotarget · 2018Review
- Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease.Advances in pharmacology (San Diego, Calif.) · 2018Review
- Roles of exosomes in the normal and diseased eye.Progress in retinal and eye research · 2017Review
- Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology.The FEBS journal · 2017Review
- Matrix Metalloproteinase Inhibitors as Investigational and Therapeutic Tools in Unrestrained Tissue Remodeling and Pathological Disorders.Progress in molecular biology and translational science · 2017Review
- Decorin interacting network: A comprehensive analysis of decorin-binding partners and their versatile functions.Matrix biology : journal of the International Society for Matrix Biology · 2016Review
- Proangiogenic Interactions of Vascular Endothelial MMP14 With VEGF Receptor 1 in VEGFA-Mediated Corneal Angiogenesis.Investigative ophthalmology & visual science · 2016Article
- Molecular underpinnings of corneal angiogenesis: advances over the past decade.International journal of ophthalmology · 2016Review
- MMP14 Cleavage of VEGFR1 in the Cornea Leads to a VEGF-Trap Antiangiogenic Effect.Investigative ophthalmology & visual science · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
BACKGROUND/
aimsDecorin has been shown to have antiangiogenic properties. In this study, we evaluate the involvement of membrane type 1-matrix metalloproteinase (MT1-MMP), a proangiogenic enzyme, in decorin cleavage in the cornea.
methodsMT1-MMP expression was confirmed immunohistochemically in keratocytes and immortalized corneal fibroblast cell lines. Corneal micropockets of bFGF were used to assess the expression of decorin and MT1-MMP. Western blotting was used to evaluate decorin degradation by MT1-MMP. Aortic ring tube formation assays were used to assay the inhibitory effect of decorin and stimulatory effect of MT1-MMP on vascular endothelial cells in vitro.
resultsWe show that MT1-MMP expression is upregulated following bFGF pellet implantation in the cornea in vivo, and that MT1-MMP cleaves decorin in a time- and concentration-dependent manner in vitro. Furthermore, the addition of MT1-MMP reduces the inhibitory effects of decorin on aortic ring tube formation in vitro. Cleavage of decorin by MT1-MMP-deficient corneal cell lysates is diminished relative to that by wild-type corneal cell lysates, and an MT1-MMP knockin restores decorin processing in vitro.
conclusionThe proangiogenic role of MT1-MMP in the cornea may be mediated, in part, by facilitated cleavage of corneal decorin.
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Registered trials
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