ArticleBlood2009
Gata1 expression driven by the alternative HS2 enhancer in the spleen rescues the hematopoietic failure induced by the hypomorphic Gata1low mutation.
Article in Blood, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 27 citations in OpenAlex.
- Gingival Response to Dental Implant: Comparison Study on the Effects of New Nanopored Laser-Treated vs. Traditional Healing Abutments.International journal of molecular sciences · 2020Trial
- GATA Transcription Factors: A Cross-Road for Erythropoiesis, Neurodevelopment, and Synucleinopathies.Developmental neurobiology · 2025Review
- Preclinical studies on the use of a P-selectin-blocking monoclonal antibody to halt progression of myelofibrosis in the Gata1Experimental hematology · 2023Article
- The CXCR1/CXCR2 Inhibitor Reparixin Alters the Development of Myelofibrosis in theFrontiers in oncology · 2022Article
- Article
- Decellularized Extracellular Matrices and Cardiac Differentiation: Study on Human Amniotic Fluid-Stem Cells.International journal of molecular sciences · 2020Article
- Article
- Immunohistochemical Results of Soft tissues Around a New Implant Healing-Abutment Surface: A Human Study.Journal of clinical medicine · 2020Article
- Novel targets to cure primary myelofibrosis from studies on Gata1IUBMB life · 2020Review
- Reappraising the role of α5 integrin and the microenvironmental support in stress erythropoiesis.Experimental hematology · 2020Article
- Spare Parts from Discarded Materials: Fetal Annexes in Regenerative Medicine.International journal of molecular sciences · 2019Review
- GATA1 insufficiencies in primary myelofibrosis and other hematopoietic disorders: consequences for therapy.Expert review of hematology · 2018Review
- The thrombopoietin/MPL axis is activated in the Gata1Blood cancer journal · 2017Article
- The spleen microenvironment influences disease transformation in a mouse model of KITScientific reports · 2017Article
- Preclinical rationale for TGF-β inhibition as a therapeutic target for the treatment of myelofibrosis.Experimental hematology · 2016Article
- Ginsenoside Rg1 improves bone marrow haematopoietic activity via extramedullary haematopoiesis of the spleen.Journal of cellular and molecular medicine · 2015Article
- The Human GATA1 Gene Retains a 5' Insulator That Maintains Chromosomal Architecture and GATA1 Expression Levels in Splenic Erythroblasts.Molecular and cellular biology · 2015Article
- A novel interaction between megakaryocytes and activated fibrocytes increases TGF-β bioavailability in the Gata1(low) mouse model of myelofibrosis.American journal of blood research · 2015Article
- Abnormal P-selectin localization during megakaryocyte development determines thrombosis in the gata1low model of myelofibrosis.Platelets · 2014Article
- Characterization of the TGF-β1 signaling abnormalities in the Gata1low mouse model of myelofibrosis.Blood · 2013Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
Abstract
Rigorously defined reconstitution assays developed in recent years have allowed recognition of the delicate relationship that exists between hematopoietic stem cells and their niches. This balance ensures that hematopoiesis occurs in the marrow under steady-state conditions. However, during development, recovery from hematopoietic stress and in myeloproliferative disorders, hematopoiesis occurs in extramedullary sites whose microenvironments are still poorly defined. The hypomorphic Gata1(low) mutation deletes the regulatory sequences of the gene necessary for its expression in hematopoietic cells generated in the marrow. By analyzing the mechanism that rescues hematopoiesis in mice carrying this mutation, we provide evidence that extramedullary microenvironments sustain maturation of stem cells that would be otherwise incapable of maturing in the marrow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.