ArticlePlant physiology2009
Arabidopsis methionine gamma-lyase is regulated according to isoleucine biosynthesis needs but plays a subordinate role to threonine deaminase.
Article in Plant physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48 citing papers in PubMed, 91 citations in OpenAlex.
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- Combined transcriptomic and metabolomic analysis revealed the salt tolerance mechanism of Populus talassica × Populus euphratica.BMC plant biology · 2025Article
- Weighted Gene Correlation Network Analysis Reveals Key Regulatory Genes Influencing Selenium Enrichment and Yield with Exogenous Selenite in Tartary Buckwheat.Plants (Basel, Switzerland) · 2025Article
- Presence of vitamin BPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Unraveling the genetics of heat tolerance in chickpea landraces (Frontiers in plant science · 2024Article
- Population Structure, Genetic Diversity and Candidate Genes for the Adaptation to Environmental Stress inPlants (Basel, Switzerland) · 2023Article
- Elucidating the importance of the catabolic enzyme, methionine-gamma-lyase, in stresses during Arabidopsis seed development and germination.Frontiers in plant science · 2023Article
- Analysis of the transcriptome of the needles and bark of Pinus radiata induced by bark stripping and methyl jasmonate.BMC genomics · 2022Article
- Global Survey, Expressions and Association Analysis ofFrontiers in genetics · 2022Article
- Effects of nicosulfuron on plant growth and sugar metabolism in sweet maize (Zea mays L.).PloS one · 2022Article
- Altitudinal Variation of Metabolites, Mineral Elements and Antioxidant Activities ofMolecules (Basel, Switzerland) · 2021Article
- Comparative transcriptomic profiling of susceptible and resistant cultivars of pigeonpea demonstrates early molecular responses during Fusarium udum infection.Scientific reports · 2021Article
- Candidate regulators and target genes of drought stress in needles and roots of Norway spruce.Tree physiology · 2021Article
- Underground isoleucine biosynthesis pathways ineLife · 2020Article
- SuppressedPlant physiology · 2020Article
- Transcript and metabolite changes during the early phase of abscisic acid-mediated induction of crassulacean acid metabolism in Talinum triangulare.Journal of experimental botany · 2019Article
- Comparative transcriptome analyses provide novel insights into the differential response of Pigeonpea (Cajanus cajan L.) and its wild relative (Cajanus platycarpus (Benth.) Maesen) to herbivory by Helicoverpa armigera (Hübner).Plant molecular biology · 2019Article
- UPLC-HRMS-based untargeted metabolic profiling reveals changes in chickpea (Cicer arietinum) metabolome following long-term drought stress.Plant, cell & environment · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The canonical pathway for isoleucine biosynthesis in plants begins with the conversion of threonine to 2-ketobutyrate by threonine deaminase (OMR1). However, demonstration of methionine gamma-lyase (MGL) activity in Arabidopsis (Arabidopsis thaliana) suggested that production of 2-ketobutyrate from methionine can also lead to isoleucine biosynthesis. Rescue of the isoleucine deficit in a threonine deaminase mutant by MGL overexpression, as well as decreased transcription of endogenous Arabidopsis MGL in a feedback-insensitive threonine deaminase mutant background, shows that these two enzymes have overlapping functions in amino acid biosynthesis. In mgl mutant flowers and seeds, methionine levels are significantly increased and incorporation of [(13)C]Met into isoleucine is decreased, but isoleucine levels are unaffected. Accumulation of free isoleucine and other branched-chain amino acids is greatly elevated in response to drought stress in Arabidopsis. Gene expression analyses, amino acid phenotypes, and labeled precursor feeding experiments demonstrate that MGL activity is up-regulated by osmotic stress but likely plays a less prominent role in isoleucine biosynthesis than threonine deaminase. The observation that MGL makes a significant contribution to methionine degradation, particularly in reproductive tissue, suggests practical applications for silencing the expression of MGL in crop plants and thereby increasing the abundance of methionine, a limiting essential amino acid.
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