ArticleCerebral cortex (New York, N.Y. : 1991)2010
Experience-dependent gene expression in adult visual cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Altered dynamic brain activity and functional connectivity in thyroid-associated ophthalmopathy.Human brain mapping · 2023Article
- Study of extravisual resting-state networks in pituitary adenoma patients with vision restoration.BMC neuroscience · 2022Article
- Study of rapid reorganization of visual neurofunctions with the resting-state functional MRI in pituitary adenoma patients with vision improvement after transsphenoidal surgery.Brain and behavior · 2021Article
- Time course of cytochrome oxidase blob plasticity in the primary visual cortex of adult monkeys after retinal laser lesions.The Journal of comparative neurology · 2019Article
- Changes in the Vision-related Resting-state Network in Pituitary Adenoma Patients After Vision Improvement.Chinese medical journal · 2015Article
- Quantification of early stages of cortical reorganization of the topographic map of V1 following retinal lesions in monkeys.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- Unravelling the development of the visual cortex: implications for plasticity and repair.Journal of anatomy · 2010Review
- Rapid axonal sprouting and pruning accompany functional reorganization in primary visual cortex.Neuron · 2009Article
Corrections and comments
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Authors and funding
3 authors.
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Abstract
Experience-dependent plasticity of the adult visual cortex underlies perceptual learning and recovery of function following central nervous system lesions. To reveal the signal transduction cascades involved in adult cortical plasticity, we utilized a model of remapping of cortical topography following binocular retinal lesions. In this model, the lesion projection zone (LPZ) of primary visual cortex (V1) recovers visually driven activity by the sprouting of horizontal axonal connections originating from the cells in the surrounding region. To explore the molecular mechanism underlying this process, we used gene microarrays from an expression library prepared from Macaque V1. By microarray analysis of gene expression levels in the LPZ and the surrounding region, and subsequent confirmation with Quantitative Real-Time polymerase chain reaction and in situ hybridization, the participation of a number of genes was observed, including the Rho GTPase family. Its role in regulation of cytoskeleton assembly provides a possible link between the alteration of neural activity and cortical functional reorganization.
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