ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2009
An imbalance of esophageal effector and regulatory T cell subsets in experimental eosinophilic esophagitis in mice.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Mouse models of eosinophilic esophagitis: molecular and translational insights.American journal of physiology. Gastrointestinal and liver physiology · 2025Review
- Significance of Interleukin (IL)-15 in IgE associated eosinophilic Esophagitis (EoE).International journal of basic and clinical immunology · 2019Article
- Signals from the various immune cells in promoting food allergy-induced eosinophilic esophagitis like disease.Asia Pacific allergy · 2019Review
- Role of Vasoactive Intestinal Peptide in Promoting the Pathogenesis of Eosinophilic Esophagitis (EoE).Cellular and molecular gastroenterology and hepatology · 2018Article
- Novel immunologic mechanisms in eosinophilic esophagitis.Current opinion in immunology · 2017Review
- Allergen-induced interleukin-18 promotes experimental eosinophilic oesophagitis in mice.Immunology and cell biology · 2015Article
- Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.Nature genetics · 2014Article
- Allergic mechanisms in eosinophilic esophagitis.Gastroenterology clinics of North America · 2014Review
- Invariant natural killer T-cell neutralization is a possible novel therapy for human eosinophilic esophagitis.Clinical & translational immunology · 2014Article
- High prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders.The Journal of allergy and clinical immunology · 2013Article
- Eosinophilic esophagitis: allergic contribution, testing, and management.Current gastroenterology reports · 2012Review
- Significance of para-esophageal lymph nodes in food or aeroallergen-induced iNKT cell-mediated experimental eosinophilic esophagitis.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Antigen presentation and MHC class II expression by human esophageal epithelial cells: role in eosinophilic esophagitis.The American journal of pathology · 2011Article
- TGF-β1: Mediator of a feedback loop in eosinophilic esophagitis--or should we really say mastocytic esophagitis?The Journal of allergy and clinical immunology · 2010Article
- Interleukin-15 expression is increased in human eosinophilic esophagitis and mediates pathogenesis in mice.Gastroenterology · 2010Article
- Common variants at 5q22 associate with pediatric eosinophilic esophagitis.Nature genetics · 2010Article
- The link between allergies and eosinophilic esophagitis: implications for management strategies.Expert review of clinical immunology · 2010Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We recently reported a critical role for T cells in the induction of eosinophilic esophagitis (EE) in mice; however, the role of specific T cell subsets in disease pathogenesis is not yet understood. In the current study, we tested the hypothesis that allergen-induced EE develops in response to the disproportion of functionally different effector and regulatory T cells in the esophagus. Fluorescence-activated cell sorter analysis was performed to examine activated T cell subsets using the cell surface activation markers CD25 and CD69. A significant increase in activated CD4(+) and CD4(-) T cells was observed in the total esophageal cells isolated from the mouse model of EE. Furthermore, an imbalance in the effector and regulatory T cells was observed in the esophagus. The esophageal CD4(+)CD45RB(high) effector T cells in allergen-challenged mice increased compared with saline-challenged mice (65.4 +/- 3.6 x 10(3) to 44.8 +/- 4.2 x 10(3)), whereas CD4(+)CD45RB(low) mostly regulatory T cells decreased in allergen-challenged mice compared with saline-challenged mice (5.8 +/- 0.9 x 10(3) from 10.2 +/- 1.7 x 10(3)). The functional characteristics were examined by analysis of the pro- and anti-inflammatory cytokine profile of purified low and high CD4(+)CD45RB subsets from the spleen. Additionally, a significantly reduced interleukin (IL)-2 production by CD4(+)CD45RB(low) cells in allergen-challenged mice compared with saline-challenged mice was observed. The reduced IL-2 in the CD4(+)CD45RB(low) subset may be associated with reduction of CD4(+)CD45RB(low) subset. In conclusion, our results suggest that local regulatory interaction of CD45RB(high) and CD45RB(low) CD4(+) T cells may be required for protective and pathogenic immunity in EE.
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