ArticleThe American journal of clinical nutrition2009
Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones.
Article in The American journal of clinical nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.
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Who cites it
82 citing papers in PubMed, 1 synthesis or guideline pooled it, 184 citations in OpenAlex.
- Health Effects of Sugar-Sweetened and Artificially Sweetened Beverages: Umbrella Review and Evidence-Based Consensus Statement of the Korean Diabetes Association and the Korean Nutrition Society.Diabetes & metabolism journal · 2026Pooled it
- Influence of the tolerability of vinegar as an oral source of short-chain fatty acids on appetite control and food intake.International journal of obesity (2005) · 2014Trial
- Central control of gastrointestinal functions in health and disease.Physiological reviews · 2026Review
- Advances in Intestinal Glucose Absorption Regulation for Ruminant Energy Efficiency Improvement.Animals : an open access journal from MDPI · 2026Review
- Review
- Chronic social defeat stress broadly inhibits gene expression in the peripheral taste system and alters taste responses in mice.Physiology & behavior · 2024Article
- A Guide to Best Practice in Sensory Analysis of Pharmaceutical Formulations.Pharmaceutics · 2023Article
- Interkingdom Detection of Bacterial Quorum-Sensing Molecules by Mammalian Taste Receptors.Microorganisms · 2023Review
- Colonic Delivery of Nutrients for Sustained and Prolonged Release of Gut Peptides: A Novel Strategy for Appetite Management.Molecular nutrition & food research · 2022Review
- Response of blood glucose and GLP-1 to different food temperature in normal subject and patients with type 2 diabetes.Nutrition & diabetes · 2022Article
- Immune Regulatory Roles of Cells Expressing Taste Signaling Elements in Nongustatory Tissues.Handbook of experimental pharmacology · 2022Article
- Oral delivery of proteins and peptides: Challenges, status quo and future perspectives.Acta pharmaceutica Sinica. B · 2021Review
- Nutrient-Induced Cellular Mechanisms of Gut Hormone Secretion.Nutrients · 2021Review
- An alternative pathway for sweet sensation: possible mechanisms and physiological relevance.Pflugers Archiv : European journal of physiology · 2020Review
- Stomach 'tastes' the food and adjusts its emptying: A neurophysiological hypothesis (Review).Experimental and therapeutic medicine · 2020Review
- Mouse intestinal tuft cells express advillin but not villin.Scientific reports · 2020Article
- Allelic variation of the Tas1r3 taste receptor gene affects sweet taste responsiveness and metabolism of glucose in F1 mouse hybrids.PloS one · 2020Article
- Distribution of duodenal tuft cells is altered in pediatric patients with acute and chronic enteropathy.Biomedical research (Tokyo, Japan) · 2020Article
- Taste Receptors in Upper Airway Innate Immunity.Nutrients · 2019Review
- A Brief Review of Genetic Approaches to the Study of Food Preferences: Current Knowledge and Future Directions.Nutrients · 2019Review
22 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Many of the receptors and downstream signaling elements involved in taste detection and transduction are also expressed in enteroendocrine cells where they underlie the chemosensory functions of the gut. In one well-known example of gastrointestinal chemosensation (the "incretin effect"), it is known that glucose that is given orally, but not systemically, induces secretion of glucagon-like peptide 1 and glucose-dependent insulinotropic peptide (the incretin hormones), which in turn regulate appetite, insulin secretion, and gut motility. Duodenal L cells express sweet taste receptors, the taste G protein gustducin, and several other taste transduction elements. Knockout mice that lack gustducin or the sweet taste receptor subunit T1r3 have deficiencies in secretion of glucagon-like peptide 1 and glucose-dependent insulinotropic peptide and in the regulation of plasma concentrations of insulin and glucose in response to orally ingested carbohydrate-ie, their incretin effect is dysfunctional. Isolated small intestine and intestinal villi from gustducin null mice displayed markedly defective glucagon-like peptide 1 secretion in response to glucose, indicating that this is a local circuit of sugar detection by intestinal cells followed by hormone secretion from these same cells. Modulating hormone secretion from gut "taste cells" may provide novel treatments for obesity, diabetes, and malabsorption syndromes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.