ArticleThe American journal of clinical nutrition2009
Luminal chemosensing and upper gastrointestinal mucosal defenses.
Article in The American journal of clinical nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 65 citations in OpenAlex.
- Bicarbonate secretion and acid/base sensing by the intestine.Pflugers Archiv : European journal of physiology · 2024Review
- Luminal chemosensing in the gastroduodenal mucosa.Current opinion in gastroenterology · 2017Review
- Acid-sensing ion channels in gastrointestinal function.Neuropharmacology · 2015Review
- Glutamate prevents intestinal atrophy via luminal nutrient sensing in a mouse model of total parenteral nutrition.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Article
- Putative interaction of brush cells with bicarbonate secreting cells in the proximal corpus mucosa.Frontiers in physiology · 2013Article
- Buffer Therapy for Cancer.Journal of nutrition & food sciences · 2012Article
- Luminal chemosensing in the duodenal mucosa.Acta physiologica (Oxford, England) · 2011Review
- Acid sensing by visceral afferent neurones.Acta physiologica (Oxford, England) · 2011Review
- Duodenal chemosensing and mucosal defenses.Digestion · 2011Article
- Lafutidine, a protective H₂ receptor antagonist, enhances mucosal defense in rat esophagus.Digestive diseases and sciences · 2010Article
- Duodenal implications in the pathophysiology of functional dyspepsia.Journal of neurogastroenterology and motility · 2010Article
- Variation in umami perception and in candidate genes for the umami receptor in mice and humans.The American journal of clinical nutrition · 2009Review
- Early milk feeding influences taste acceptance and liking during infancy.The American journal of clinical nutrition · 2009Article
- Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes.The American journal of clinical nutrition · 2009Article
- Taste receptors for umami: the case for multiple receptors.The American journal of clinical nutrition · 2009Article
- Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones.The American journal of clinical nutrition · 2009Article
- Regulation of glutamate metabolism and insulin secretion by glutamate dehydrogenase in hypoglycemic children.The American journal of clinical nutrition · 2009Review
- Umami taste transduction mechanisms.The American journal of clinical nutrition · 2009Review
- The blood-brain barrier and glutamate.The American journal of clinical nutrition · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The upper gastrointestinal mucosa is exposed to endogenous and exogenous substances, including gastric acid, carbon dioxide, and foodstuffs. Physiologic processes such as secretion, digestion, absorption, and motility occur in the gastrointestinal tract in response to ingested substances, which implies the presence of mucosal sensors. We hypothesize that mucosal acid sensors and tastelike receptors are important components of the mucosal chemosensing system. We have shown that luminal acid/carbon dioxide is sensed via ecto- and cytosolic carbonic anhydrases and ion transporters in the epithelial cells and via acid sensors on the afferent nerves in the duodenum and esophagus. Furthermore, a luminal l-glutamate signal is mediated via mucosal l-glutamate receptors with activation of afferent nerves and cyclooxygenase in the duodenum, which suggests the presence of luminal l-glutamate sensing. These luminal chemosensors help to activate mucosal defense mechanisms to maintain the mucosal integrity and physiologic responses of the upper gastrointestinal tract. Because neural pathways are components of the luminal chemosensory system, investigation of these pathways may help to identify novel molecular targets in the treatment and prevention of mucosal injury and visceral sensation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.