ReviewThe American journal of clinical nutrition2009
Glutamate taste and appetite in laboratory mice: physiologic and genetic analyses.
Review in The American journal of clinical nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 53 citations in OpenAlex.
- Metabolic effects of a submaximal dose of pink salt and monosodium glutamate in experimental rats.Heliyon · 2024Article
- Absinthin, an agonist of the bitter taste receptor hTAS2R46, uncovers an ER-to-mitochondria CaThe Journal of biological chemistry · 2019Article
- Taste sensitivity to a mixture of monosodium glutamate and inosine 5'-monophosphate by mice lacking both subunits of the T1R1+T1R3 amino acid receptor.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Flavor Preferences Conditioned by Dietary Glutamate.Advances in nutrition (Bethesda, Md.) · 2016Review
- Genetics of Amino Acid Taste and Appetite.Advances in nutrition (Bethesda, Md.) · 2016Review
- Taste dysfunction in BTBR mice due to a mutation of Itpr3, the inositol triphosphate receptor 3 gene.Physiological genomics · 2013Article
- Early life opportunities for prevention of diabetes in low and middle income countries.BMC public health · 2012Review
- Variation in umami perception and in candidate genes for the umami receptor in mice and humans.The American journal of clinical nutrition · 2009Review
- Umami taste transduction mechanisms.The American journal of clinical nutrition · 2009Review
- Regulation of glutamate metabolism and insulin secretion by glutamate dehydrogenase in hypoglycemic children.The American journal of clinical nutrition · 2009Review
- The blood-brain barrier and glutamate.The American journal of clinical nutrition · 2009Article
- Luminal chemosensing and upper gastrointestinal mucosal defenses.The American journal of clinical nutrition · 2009Article
- Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones.The American journal of clinical nutrition · 2009Article
- Taste receptors for umami: the case for multiple receptors.The American journal of clinical nutrition · 2009Article
- Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes.The American journal of clinical nutrition · 2009Article
- Early milk feeding influences taste acceptance and liking during infancy.The American journal of clinical nutrition · 2009Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
This article provides an overview of our studies of variation in voluntary glutamate consumption in mice. In 2-bottle preference tests, mice from the C57BL/6ByJ (B6) strain consume more monosodium l-glutamate (MSG) than do mice from the 129P3/J (129) strain. We used these mice to study physiologic and genetic mechanisms that underlie the strain differences in glutamate intake. Our genetic analyses showed that differences between B6 mice and 129 mice in MSG consumption are unrelated to strain variation in consumption of sodium or sweeteners and therefore are attributed to mechanisms specific for glutamate. These strain differences could be due to variation in responses to either taste or postingestive effects of glutamate. To examine the role of taste responsiveness, we measured MSG-evoked activity in gustatory nerves and showed that it is similar in B6 and 129 mice. On the other hand, strain-specific postingestive effects of glutamate were evident from our finding that exposure to MSG increases its consumption in B6 mice and decreases its consumption in 129 mice. We therefore examined whether B6 mice and 129 mice differ in postingestive metabolism of glutamate. We showed that, after intragastric administration of MSG, the MSG is preferentially metabolized through gluconeogenesis in B6 mice, whereas thermogenesis is the predominant process for 129 mice. We hypothesize that a process related to gluconeogenesis of the ingested glutamate generates the rewarding stimulus, which probably occurs in the liver before glucose enters the general circulation, and that the glutamate-induced postingestive thermogenesis generates an aversive stimulus. Our animal model studies raise the question of whether humans also vary in glutamate metabolism in a manner that influences their glutamate preference, consumption, and postingestive processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.