ArticleJournal of neurophysiology2009
Control of a depolarizing GABAergic input in an auditory coincidence detection circuit.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Cellular Strategies for Frequency-Dependent Computation of Interaural Time Difference.Frontiers in synaptic neuroscience · 2022Review
- Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem.Frontiers in neural circuits · 2020Review
- Activity-dependent synaptic integration and modulation of bilateral excitatory inputs in an auditory coincidence detection circuit.The Journal of physiology · 2018Article
- Anatomy and Physiology of Metabotropic Glutamate Receptors in Mammalian and Avian Auditory System.HSOA trends in anatomy and physiology · 2018Article
- Metabotropic glutamate and GABA receptors modulate cellular excitability and glutamatergic transmission in chicken cochlear nucleus angularis neurons.Hearing research · 2017Article
- Intrinsic plasticity induced by group II metabotropic glutamate receptors via enhancement of high-threshold KV currents in sound localizing neurons.Neuroscience · 2016Article
- Metabotropic glutamate receptors in auditory processing.Neuroscience · 2014Review
- GABAA receptor-mediated tonic depolarization in developing neural circuits.Molecular neurobiology · 2014Review
- Neuronal specializations for the processing of interaural difference cues in the chick.Frontiers in neural circuits · 2014Review
- Glycinergic transmission modulates GABAergic inhibition in the avian auditory pathway.Frontiers in neural circuits · 2014Article
- Interplay between low threshold voltage-gated K(+) channels and synaptic inhibition in neurons of the chicken nucleus laminaris along its frequency axis.Frontiers in neural circuits · 2014Article
- The natural history of sound localization in mammals--a story of neuronal inhibition.Frontiers in neural circuits · 2014Article
- Activation of synaptic group II metabotropic glutamate receptors induces long-term depression at GABAergic synapses in CNS neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Activation of metabotropic glutamate receptors improves the accuracy of coincidence detection by presynaptic mechanisms in the nucleus laminaris of the chick.The Journal of physiology · 2013Article
- Two GABAA responses with distinct kinetics in a sound localization circuit.The Journal of physiology · 2012Article
- Synaptic activity-induced Ca(2+) signaling in avian cochlear nucleus magnocellularis neurons.Neuroscience research · 2012Article
- Development of GPCR modulation of GABAergic transmission in chicken nucleus laminaris neurons.PloS one · 2012Article
- Sound localization: Jeffress and beyond.Current opinion in neurobiology · 2011Review
- Ambient GABA-activated tonic inhibition sharpens auditory coincidence detection via a depolarizing shunting mechanism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Dynamic spike thresholds during synaptic integration preserve and enhance temporal response properties in the avian cochlear nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
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Authors and funding
3 authors.
Funding
Abstract
Neurons in the chicken nucleus laminaris (NL), the third-order auditory neurons that detect the interaural time differences that enable animals to localize sounds in the horizontal plane, receive glutamatergic excitation from the cochlear nucleus magnocellularis (NM) and GABAergic inhibition from the ipsilateral superior olivary nucleus. Here, we study metabotropic glutamate receptor (mGluR)- and GABAB receptor (GABABR)-mediated modulation of synaptic transmission in NL neurons. Gramicidin-perforated recordings from acute brain stem slice preparations showed that the reversal potential of the GABAergic responses in NL neurons was more depolarized than the spike threshold. Activation of the GABAergic input produced a mix of inhibitory and excitatory actions in NL neurons. The inhibitory action is known to be critical in improving the acuity of temporal processing of sounds. The excitatory action, however, would reduce the phase locking fidelity of NL neurons in response to their excitatory inputs from the NM. We show that activation of presynaptic mGluRs or GABABRs by either exogenous agonists or synaptically released neurotransmitters reduced the GABAergic responses, preventing the excitatory action of GABA while leaving the inhibitory action intact. Unlike most CNS synapses, the glutamatergic transmission in the NL was not modulated by either mGluRs or GABABRs, indicating that fixed (nonmodulatory) excitatory inputs to the NL may be optimal for coincidence detection. This study contributes to our understanding of how selective neuromodulation is achieved to suit a particular function of neuronal circuits in the brain.
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