ArticleGenes & development2009
Multiplicity of DNA end resection machineries in chromosome break repair.
Article in Genes & development, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- DNA2 protein destruction dictates DNA hyperexcision, cGAS-STING activation, and innate immune response in CDK12-deregulated cancers.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mutant huntingtin protein induces MLH1 degradation, DNA hyperexcision, and cGAS-STING-dependent apoptosis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Beta human papillomavirus 8 E6 allows colocalization of non-homologous end joining and homologous recombination repair factors.PLoS pathogens · 2022Article
- MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway.Cancer cell · 2021Article
- The deubiquitinase OTUD5 regulates Ku80 stability and non-homologous end joining.Cellular and molecular life sciences : CMLS · 2019Article
- A DNA nick at Ku-blocked double-strand break ends serves as an entry site for exonuclease 1 (Exo1) or Sgs1-Dna2 in long-range DNA end resection.The Journal of biological chemistry · 2018Article
- hDNA2 nuclease/helicase promotes centromeric DNA replication and genome stability.The EMBO journal · 2018Article
- A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy.EBioMedicine · 2016Article
- Phosphorylation of Ku dictates DNA double-strand break (DSB) repair pathway choice in S phase.Nucleic acids research · 2016Article
- Biochemical mechanism of DSB end resection and its regulation.DNA repair · 2015Review
- BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the cell cycle.Nucleic acids research · 2014Article
- 53BP1, BRCA1, and the choice between recombination and end joining at DNA double-strand breaks.Molecular and cellular biology · 2014Review
- Bacillus subtilis RecA and its accessory factors, RecF, RecO, RecR and RecX, are required for spore resistance to DNA double-strand break.Nucleic acids research · 2014Article
- Multifaceted role of the Topo IIIα-RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resection.Nucleic acids research · 2014Article
- DNA end resection is needed for the repair of complex lesions in G1-phase human cells.Cell cycle (Georgetown, Tex.) · 2014Article
- Human nuclease/helicase DNA2 alleviates replication stress by promoting DNA end resection.Cancer research · 2012Article
- Eukaryotic DNA damage checkpoint activation in response to double-strand breaks.Cellular and molecular life sciences : CMLS · 2012Review
- Persistently bound Ku at DNA ends attenuates DNA end resection and homologous recombination.DNA repair · 2012Article
- Polynucleotide phosphorylase exonuclease and polymerase activities on single-stranded DNA ends are modulated by RecN, SsbA and RecA proteins.Nucleic acids research · 2011Article
- Characterization of the endonuclease and ATP-dependent flap endo/exonuclease of Dna2.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
DNA end resection is critical for chromosome break repair by homologous recombination and influences the efficiency of repair by nonhomologous DNA end joining. An elegant study by Sinha and colleagues (pp. 1423-1437) published in the June 15, 2009, issue of Genes & Development identified a novel mycobacterial DNA end resection protein complex, AdnAB, that harbors dual DNA motor and dual nuclease functions. Sinha and colleagues also demonstrated that the DNA end-binding protein complex Ku regulates the activity of AdnAB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.