ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Induction of neuronal vascular endothelial growth factor expression by cAMP in the dentate gyrus of the hippocampus is required for antidepressant-like behaviors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 66 citations in OpenAlex.
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- Antidepressant medication and ocular factors in association with the need for anti-VEGF retreatment in neovascular age-related macular degeneration.The British journal of ophthalmology · 2019Observational
- Adrb2 controls glucose homeostasis by developmental regulation of pancreatic islet vasculature.eLife · 2018Article
- Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice.Experimental & molecular medicine · 2018Article
- Mechanisms regulating angiogenesis underlie seasonal control of pituitary function.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Antidepressant Effects of Aripiprazole Augmentation for Cilostazol-Treated Mice Exposed to Chronic Mild Stress after Ischemic Stroke.International journal of molecular sciences · 2017Article
- A critical role for VEGF and VEGFR2 in NMDA receptor synaptic function and fear-related behavior.Molecular psychiatry · 2016Article
- Alterations in leukocyte transcriptional control pathway activity associated with major depressive disorder and antidepressant treatment.Translational psychiatry · 2016Article
- Control of adult neurogenesis by programmed cell death in the mammalian brain.Molecular brain · 2016Review
- Corticotropin Releasing Hormone and Urocortin 3 Stimulate Vascular Endothelial Growth Factor Expression through the cAMP/CREB Pathway.The Journal of biological chemistry · 2015Article
- Hippocampal PPARδ Overexpression or Activation Represses Stress-Induced Depressive Behaviors and Enhances Neurogenesis.The international journal of neuropsychopharmacology · 2015Article
- Applying stereotactic injection technique to study genetic effects on animal behaviors.Journal of visualized experiments : JoVE · 2015Article
- Pathological hypertrophy reverses β2-adrenergic receptor-induced angiogenesis in mouse heart.Physiological reports · 2015Article
- Rodent models of depression: neurotrophic and neuroinflammatory biomarkers.BioMed research international · 2014Review
- Second messenger/signal transduction pathways in major mood disorders: moving from membrane to mechanism of action, part I: major depressive disorder.CNS spectrums · 2013Review
- Vascular growth factors in neuropsychiatry.Cellular and molecular life sciences : CMLS · 2013Review
- Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 3 countries.
Funding
Abstract
The cAMP cascade and vascular endothelial growth factor (VEGF) are critical modulators of depression. Here we have tested whether the antidepressive effect of the cAMP cascade is mediated by VEGF in the adult hippocampus. We used a conditional genetic system in which the Aplysia octopamine receptor (Ap oa(1)), a G(s)-coupled receptor, is transgenically expressed in the forebrain neurons of mice. Chronic activation of the heterologous Ap oa(1) by its natural ligand evoked antidepressant-like behaviors, accompanied by enhanced phosphorylation of cAMP response element-binding protein and transcription of VEGF in hippocampal dentate gyrus (DG) neurons. Selective knockdown of VEGF in these cells during the period of cAMP elevation inhibited the antidepressant-like behaviors. These findings reveal a molecular interaction between the cAMP cascade and VEGF expression, and the pronounced behavioral consequences of this interaction shed light on the mechanism underlying neuronal VEGF functions in antidepression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.