ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
The functional equivalence of ascending and parallel fiber inputs in cerebellar computation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 51 citations in OpenAlex.
- The spiny relationship between parallel fibers, climbing fibers, and Purkinje cells.Frontiers in physiology · 2025Review
- Article
- Human Purkinje cells outperform mouse Purkinje cells in dendritic complexity and computational capacity.Communications biology · 2024Article
- What Can We Learn from Synaptic Connectivity Maps about Cerebellar Internal Models?Cerebellum (London, England) · 2023Review
- Anisotropy and Frequency Dependence of Signal Propagation in the Cerebellar Circuit Revealed by High-Density Multielectrode Array Recordings.Biomedicines · 2023Article
- Cerebellar connectivity maps embody individual adaptive behavior in mice.Nature communications · 2022Article
- Simulation of a Human-Scale Cerebellar Network Model on the K Computer.Frontiers in neuroinformatics · 2020Article
- Reconstruction and Simulation of a Scaffold Model of the Cerebellar Network.Frontiers in neuroinformatics · 2019Article
- Cerebellar Modules and Their Role as Operational Cerebellar Processing Units: A Consensus paper [corrected].Cerebellum (London, England) · 2018Review
- Movement Rate Is Encoded and Influenced by Widespread, Coherent Activity of Cerebellar Molecular Layer Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Synaptic Activation of a Detailed Purkinje Cell Model Predicts Voltage-Dependent Control of Burst-Pause Responses in Active Dendrites.Frontiers in cellular neuroscience · 2017Article
- Stereotyped spatial patterns of functional synaptic connectivity in the cerebellar cortex.eLife · 2016Article
- Modeling the Cerebellar Microcircuit: New Strategies for a Long-Standing Issue.Frontiers in cellular neuroscience · 2016Review
- Climbing fibers mediate vestibular modulation of both "complex" and "simple spikes" in Purkinje cells.Cerebellum (London, England) · 2015Review
- The 40-year history of modeling active dendrites in cerebellar Purkinje cells: emergence of the first single cell "community model".Frontiers in computational neuroscience · 2015Review
- The spatiotemporal organization of cerebellar network activity resolved by two-photon imaging of multiple single neurons.Frontiers in cellular neuroscience · 2014Article
- Reevaluation of the beam and radial hypotheses of parallel fiber action in the cerebellar cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Efficient generation of reciprocal signals by inhibition.Journal of neurophysiology · 2012Article
- Calcium influx measured at single presynaptic boutons of cerebellar granule cell ascending axons and parallel fibers.Cerebellum (London, England) · 2012Article
- Roles of molecular layer interneurons in sensory information processing in mouse cerebellar cortex Crus II in vivo.PloS one · 2012Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
At the center of the computational cerebellar circuitry are Purkinje cells, which integrate synaptic inputs from >150,000 granule cell inputs. Traditional theories of cerebellar function assume that all granule cell inputs are comparable. However, it has recently been suggested that the two anatomically distinct granule cell inputs, ascending and parallel fiber, have different functional roles. By systematically examining the efficacy of patches of granule cells with photostimulation, we found no differences in the efficacy of the two inputs in driving the activity of, or in producing postsynaptic currents in, Purkinje cells in cerebellar slices in vitro. We also found that the activity of Purkinje cells was significantly increased upon stimulation of lateral granule cells in vivo. Moreover, when we estimated parallel fiber and ascending apparent unitary EPSC amplitudes using photostimulation in cerebellar slices in vitro, we found them to be indistinguishable. These results are inconsistent with differential functional roles for these two inputs. Instead, our data support theories of cerebellar computation that consider granule cell inputs to be functionally comparable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.