ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Parallel ON and OFF cone bipolar inputs establish spatially coextensive receptive field structure of blue-yellow ganglion cells in primate retina.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed.
- Filter, Detector, Predictor: The expanding repertoire of retinal computation in vertebrates.Vision research · 2026Review
- Decoding the roles of bipolar, amacrine, and horizontal cells.Handbook of clinical neurology · 2026Review
- S-cone-specific circuitry in the outer plexiform layer of a cone-dominant mammal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Human pluripotent stem cell-derived retinal ganglion cells: advances in differentiation and translational applications.Molecular medicine (Cambridge, Mass.) · 2025Review
- Regional tuning of photoreceptor adaptation in the primate retina.Nature communications · 2024Article
- A circuit motif for color in the human foveal retina.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Applying Super-Resolution and Tomography Concepts to Identify Receptive Field Subunits in the Retina.PLoS computational biology · 2024Article
- The mechanism of human color vision and potential implanted devices for artificial color vision.Frontiers in neuroscience · 2024Review
- Color appearance and the end of Hering's Opponent-Colors Theory.Trends in cognitive sciences · 2023Review
- Comparative connectomics reveals noncanonical wiring for color vision in human foveal retina.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- MFN1 augmentation prevents retinal degeneration in a Charcot-Marie-Tooth type 2A mouse model.iScience · 2023Article
- Synaptic inputs to displaced intrinsically-photosensitive ganglion cells in macaque retina.Scientific reports · 2022Article
- Retinal ganglion cells expressing CaM kinase II in human and nonhuman primates.The Journal of comparative neurology · 2022Article
- Origins of direction selectivity in the primate retina.Nature communications · 2022Article
- Ganglion cells in larval zebrafish retina integrate inputs from multiple cone types.Journal of neurophysiology · 2021Article
- Color and cellular selectivity of retinal ganglion cell subtypes through frequency modulation of electrical stimulation.Scientific reports · 2021Article
- Visual properties of human retinal ganglion cells.PloS one · 2021Article
- Neural circuits in the mouse retina support color vision in the upper visual field.Nature communications · 2020Article
- Modeling Circadian Phototransduction: Retinal Neurophysiology and Neuroanatomy.Frontiers in neuroscience · 2020Article
- Horizontal Cell Feedback to Cone Photoreceptors in Mammalian Retina: Novel Insights From the GABA-pH Hybrid Model.Frontiers in cellular neuroscience · 2020Review
6 more citing papers are in PubMed but not listed here.
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Abstract
In the primate retina the small bistratified, "blue-yellow" color-opponent ganglion cell receives parallel ON-depolarizing and OFF-hyperpolarizing inputs from short (S)-wavelength sensitive and combined long (L)- and middle (M)-wavelength sensitive cone photoreceptors, respectively. However, the synaptic pathways that create S versus LM cone-opponent receptive field structure remain controversial. Here, we show in the macaque monkey retina in vitro that at photopic light levels, when an identified rod input is excluded, the small bistratified cell displays a spatially coextensive receptive field in which the S-ON-input is in spatial, temporal, and chromatic balance with the LM-OFF-input. ON pathway block with l-AP-4, the mGluR6 receptor agonist, abolished the S-ON response but spared the LM-OFF response. The isolated LM component showed a center-surround receptive field structure consistent with an input from OFF-center, ON-surround "diffuse" cone bipolar cells. Increasing retinal buffering capacity with HEPES attenuated the LM-ON surround component, consistent with a non-GABAergic outer retina feedback mechanism for the bipolar surround. The GABAa/c receptor antagonist picrotoxin and the glycine receptor antagonist strychnine did not affect chromatic balance or the basic coextensive receptive field structure, suggesting that the LM-OFF field is not generated by an inner retinal inhibitory pathway. We conclude that the opponent S-ON and LM-OFF responses originate from the excitatory receptive field centers of S-ON and LM-OFF cone bipolar cells, and that the LM-OFF- and ON-surrounds of these parallel bipolar inputs largely cancel, explaining the small, spatially coextensive but spectrally antagonistic receptive field structure of the blue-ON ganglion cell.
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