ArticleJournal of clinical microbiology2009
Population-based molecular epidemiology of leprosy in Cebu, Philippines.
Article in Journal of clinical microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00315809 (Molecular Epidemiology of Leprosy - Philippines), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Molecular Epidemiology of Leprosy - Philippines
Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- Transmission Interruption of Leprosy in the Philippines: An Update on the Current Program Priorities and Interventions.Tropical medicine and infectious disease · 2026Article
- Molecular epidemiological characteristics ofFrontiers in public health · 2024Article
- Genotyping ofIranian journal of microbiology · 2023Article
- Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil.Revista da Sociedade Brasileira de Medicina Tropical · 2023Article
- Pathogenicity and virulence ofVirulence · 2022Review
- Genotyping comparison of Mycobacterium leprae isolates by VNTR analysis from nasal samples in a Brazilian endemic region.Pathogens and global health · 2018Article
- Genotyping of Mycobacterium leprae for better understanding of leprosy transmission in Fortaleza, Northeastern Brazil.PLoS neglected tropical diseases · 2017Article
- New Insights into the Geographic Distribution of Mycobacterium leprae SNP Genotypes Determined for Isolates from Leprosy Cases Diagnosed in Metropolitan France and French Territories.PLoS neglected tropical diseases · 2015Article
- Characterization of Mycobacterium leprae Genotypes in China--Identification of a New Polymorphism C251T in the 16S rRNA Gene.PloS one · 2015Article
- Mycobacterium leprae in Colombia described by SNP7614 in gyrA, two minisatellites and geography.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2013Article
- Molecular, ethno-spatial epidemiology of leprosy in China: novel insights for tracing leprosy in endemic and non endemic provinces.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2013Article
- Identification of urban leprosy clusters.TheScientificWorldJournal · 2013Article
- Distribution of Mycobacterium leprae strains among cases in a rural and urban population of Maharashtra, India.Journal of clinical microbiology · 2012Article
- Real-time PCR and high-resolution melt analysis for rapid detection of Mycobacterium leprae drug resistance mutations and strain types.Journal of clinical microbiology · 2012Article
- Transmission of dapsone-resistant leprosy detected by molecular epidemiological approaches.Antimicrobial agents and chemotherapy · 2011Article
- Serum metabolomics reveals higher levels of polyunsaturated fatty acids in lepromatous leprosy: potential markers for susceptibility and pathogenesis.PLoS neglected tropical diseases · 2011Article
- DNA fingerprinting of Mycobacterium leprae strains using variable number tandem repeat (VNTR) - fragment length analysis (FLA).Journal of visualized experiments : JoVE · 2011Article
- Molecular typing of Mycobacterium leprae strains from northern India using short tandem repeats.The Indian journal of medical research · 2011Article
- Transmission of leprosy in Qiubei County, Yunnan, China: insights from an 8-year molecular epidemiology investigation.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2011Article
- Molecular epidemiology of Mycobacterium leprae as determined by structure-neighbor clustering.Journal of clinical microbiology · 2010Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
To address the persisting problem of leprosy in Cebu, Philippines, we compiled a database of more than 200 patients who attend an established referral skin clinic. We described the patient characteristics in conventional demographic parameters and also applied multiple-locus variable-number tandem-repeat (VNTR) analysis (MLVA) and single nucleotide polymorphism (SNP) typing for Mycobacterium leprae in biopsied skin lesion samples. These combined approaches revealed that transmission is ongoing, with the affected including the young Cebuano population under 40 years of age in both crowded cities and rural areas of the island. The emergence of multicase families (MCF) is indicative of infection unconstrained by standard care measures. For the SNPs, we designed a low-cost PCR-restriction fragment length polymorphism typing method. MLVA in M. leprae was highly discriminatory in this population yet could retain broad groups, as defined by the more stable SNPs, implying temporal marker stability suitable for interpreting population structures and evolution. The majority of isolates belong to an Asian lineage (SNP type 1), and the rest belong to a putative postcolonial lineage (SNP type 3). Specific alleles at two VNTR loci, (GGT)5 and 21-3, were highly associated with SNP type 3 in this population. MLVA identified M. leprae genotype associations for patients with known epidemiological links such as in MCFs and in some villages. These methods provide a molecular database and a rational framework for targeted approaches to search and confirm leprosy transmission in various scenarios.
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