ArticleProceedings of the National Academy of Sciences of the United States of America2009
Imaging rapid redistribution of sensory-evoked depolarization through existing cortical pathways after targeted stroke in mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Cycling using functional electrical stimulation therapy to improve motor function and activity in post-stroke individuals in early subacute phase: a systematic review with meta-analysis.Biomedical engineering online · 2024Pooled it
- Fluorescent sensors for intracellular signaling in the brain: imaging neurons, glia, and vascular cells.Neurophotonics · 2025Article
- Neural repair mechanisms after ischemic stroke.Inflammation and regeneration · 2025Review
- Article
- Functional (ir)Relevance of Posterior Parietal Cortex during Audiovisual Change Detection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Rapid and Bihemispheric Reorganization of Neuronal Activity in Premotor Cortex after Brain Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Cholinergic upregulation by optogenetic stimulation of nucleus basalis after photothrombotic stroke in forelimb somatosensory cortex improves endpoint and motor but not sensory control of skilled reaching in mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Cortical propagation tracks functional recovery after stroke.PLoS computational biology · 2021Article
- Article
- Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Capillary flow homogenization during functional activation revealed by optical coherence tomography angiography based capillary velocimetry.Scientific reports · 2018Article
- Recovery of the 20 Hz Rebound to Tactile and Proprioceptive Stimulation after Stroke.Neural plasticity · 2018Article
- Inhibiting Histone Deacetylase 2 (HDAC2) Promotes Functional Recovery From Stroke.Journal of the American Heart Association · 2017Article
- Opening a New Time Window for Treatment of Stroke by Targeting HDAC2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- A Large Lateral Craniotomy Procedure for Mesoscale Wide-field Optical Imaging of Brain Activity.Journal of visualized experiments : JoVE · 2017Article
- Time-sensitive reorganization of the somatosensory cortex poststroke depends on interaction between Hebbian and homeoplasticity: a simulation study.Journal of neurophysiology · 2014Article
- Real-time high resolution laser speckle imaging of cerebral vascular changes in a rodent photothrombosis model.Biomedical optics express · 2014Article
- Ministrokes in channelrhodopsin-2 transgenic mice reveal widespread deficits in motor output despite maintenance of cortical neuronal excitability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence suggests that recovery from stroke damage results from the production of new synaptic pathways within surviving brain regions over weeks. To address whether brain function might redistribute more rapidly through preexisting pathways, we examined patterns of sensory-evoked depolarization in mouse somatosensory cortex within hours after targeted stroke to a subset of the forelimb sensory map. Brain activity was mapped with voltage-sensitive dye imaging allowing millisecond time resolution over 9 mm(2) of brain. Before targeted stroke, we report rapid activation of the forelimb area within 10 ms of contralateral forelimb stimulation and more delayed activation of related areas of cortex such as the hindlimb sensory and motor cortices. After stroke to a subset of the forelimb somatosensory cortex map, function was lost in ischemic areas within the forelimb map center, but maintained in regions 200-500 microm blood flow deficits indicating the size of a perfused, but nonfunctional, penumbra. In many cases, stroke led to only partial loss of the forelimb map, indicating that a subset of a somatosensory domain can function on its own. Within the forelimb map spared by stroke, forelimb-stimulated responses became delayed in kinetics, and their center of activity shifted into adjacent hindlimb and posterior-lateral sensory areas. We conclude that the focus of forelimb-specific somatosensory cortex activity can be rapidly redistributed after ischemic damage. Given that redistribution occurs within an hour, the effect is likely to involve surviving accessory pathways and could potentially contribute to rapid behavioral compensation or direct future circuit rewiring.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.