ArticleThe Journal of biological chemistry2009
Generation of digital responses in stress sensors.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- p38α and p38β regulate osmostress-induced apoptosis.The Journal of biological chemistry · 2025Article
- Understanding MAPK Signaling Pathways in Apoptosis.International journal of molecular sciences · 2020Review
- Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3-dependent Proteolysis of JNK1-2 and Bid.The Journal of biological chemistry · 2015Article
- The role of T cell receptor signaling thresholds in guiding T cell fate decisions.Current opinion in immunology · 2015Review
- Article
- Osmostress-induced apoptosis in Xenopus oocytes: role of stress protein kinases, calpains and Smac/DIABLO.PloS one · 2015Article
- Article
- Digital kinases: A cell model for sensing, integrating and making choices.Communicative & integrative biology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultrasensitivity, hysteresis (a form of biochemical memory), and all-or-none (digital) responses are important signaling properties for the control of irreversible processes and are well characterized in the c-Jun N-terminal kinase (JNK) system using Xenopus oocytes. Our aim was to study these properties in the AMP-activated protein kinase (AMPK) signaling system under stress conditions that could engage a cell death program, and compare them to the JNK responses. After characterization of Xenopus AMPK, we show here that the response to antimycin (nonapoptotic) was slightly cooperative and graded (analog) in individual oocytes, whereas the response to sorbitol (which induced cytochrome c release and caspase activation) was ultrasensitive, digital in single cells, and without hysteresis, hallmarks of a monostable system. Moreover, initial graded responses of AMPK and JNK turned into digital during a critical period for the execution of the cell death program, although single cell analysis did not show complete correlation between AMPK or JNK activation and cytochrome c release. We propose a model where the life or death decision in the cell is made by integration of multiple digital signals from stress sensors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.