ArticleJournal of the Royal Society, Interface2009
Combining structure and dynamics: non-denaturing high-pressure effect on lysozyme in solution.
Article in Journal of the Royal Society, Interface, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Fast calculation of small-angle scattering profiles of dense protein solutions modeled at the all-atom level.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Small-angle scattering from flat bilayers containing correlated scattering length density inhomogeneities.Journal of applied crystallography · 2023Article
- Unravelling the Adaptation Mechanisms to High Pressure in Proteins.International journal of molecular sciences · 2022Article
- Taurine Stabilizing Effect on Lysozyme.Life (Basel, Switzerland) · 2022Article
- SAXS Reveals the Stabilization Effects of Modified Sugars on Model Proteins.Life (Basel, Switzerland) · 2022Article
- Adaptations for Pressure and Temperature in Dihydrofolate Reductases.Microorganisms · 2021Article
- The dimer-monomer equilibrium of SARS-CoV-2 main protease is affected by small molecule inhibitors.Scientific reports · 2021Article
- Comprehensive Structural and Thermodynamic Analysis of Prefibrillar WT α-Synuclein and Its G51D, E46K, and A53T Mutants by a Combination of Small-Angle X-ray Scattering and Variational Bayesian Weighting.Journal of chemical information and modeling · 2020Article
- Gelling without Structuring: A SAXS Study of the Interactions among DNA Nanostars.Langmuir : the ACS journal of surfaces and colloids · 2020Article
- Trehalose Effect on the Aggregation of Model Proteins into Amyloid Fibrils.Life (Basel, Switzerland) · 2020Article
- K vs. Na Effects on the Self-Assembly of Guanosine 5'-Monophosphate: A Solution SAXS Structural StudyNanomaterials (Basel, Switzerland) · 2020Article
- FTIR Spectroscopic Study of the Secondary Structure of Globular Proteins in Aqueous Protic Ionic Liquids.Frontiers in chemistry · 2019Article
- The effects of pressure on the energy landscape of proteins.Scientific reports · 2018Article
- Thermodynamics of lipid multi-lamellar vesicles in presence of sterols at high hydrostatic pressure.Scientific reports · 2017Article
- Pressure effects on collective density fluctuations in water and protein solutions.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Extreme biophysics: Enzymes under pressure.Journal of computational chemistry · 2017Article
- High protein flexibility and reduced hydration water dynamics are key pressure adaptive strategies in prokaryotes.Scientific reports · 2016Article
- A review of multi-domain and flexible molecular chaperones studies by small-angle X-ray scattering.Biophysical reviews · 2016Review
- Proteins in binary solvents.Biophysical reviews · 2016Review
- Structural and Thermodynamic Properties of Septin 3 Investigated by Small-Angle X-Ray Scattering.Biophysical journal · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small-angle X-ray scattering (SAXS) and elastic and quasi-elastic neutron scattering techniques were used to investigate the high-pressure-induced changes on interactions, the low-resolution structure and the dynamics of lysozyme in solution. SAXS data, analysed using a global-fit procedure based on a new approach for hydrated protein form factor description, indicate that lysozyme completely maintains its globular structure up to 1500 bar, but significant modifications in the protein-protein interaction potential occur at approximately 600-1000 bar. Moreover, the mass density of the protein hydration water shows a clear discontinuity within this pressure range. Neutron scattering experiments indicate that the global and the local lysozyme dynamics change at a similar threshold pressure. A clear evolution of the internal protein dynamics from diffusing to more localized motions has also been probed. Protein structure and dynamics results have then been discussed in the context of protein-water interface and hydration water dynamics. According to SAXS results, the new configuration of water in the first hydration layer induced by pressure is suggested to be at the origin of the observed local mobility changes.
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