ReviewMolecular oncology2009
Endocytosis and spatial restriction of cell signaling.
Review in Molecular oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed.
- Repurposed cAMP-Modulating Agents Enhance 5-Fluorouracil Response Through Membrane-Dependent Mechanisms.Membranes · 2026Review
- Optimizing microRNA delivery via albumin-decorated nanostructured lipid carriers.International journal of pharmaceutics: X · 2025Article
- Spatial Regulation of Endocytosis and Adhesion Formation Governs Breast Cancer Cell Migration Under Confinement.Bioengineering (Basel, Switzerland) · 2025Article
- PDGFR dimer-specific activation, trafficking and downstream signaling dynamics.Journal of cell science · 2022Article
- Stomatin modulates adipogenesis through the ERK pathway and regulates fatty acid uptake and lipid droplet growth.Nature communications · 2022Article
- Endocytosis in the context-dependent regulation of individual and collective cell properties.Nature reviews. Molecular cell biology · 2021Review
- The multifaceted role of cell cycle regulators in the coordination of growth and metabolism.The FEBS journal · 2021Review
- The emerging complexity of PDGFRs: activation, internalization and signal attenuation.Biochemical Society transactions · 2020Review
- AMOT130 drives BMP-SMAD signaling at the apical membrane in polarized cells.Molecular biology of the cell · 2020Article
- Dynamic Polarization of Rab11a Modulates Crb2a Localization and Impacts Signaling to Regulate Retinal Neurogenesis.Frontiers in cell and developmental biology · 2020Article
- Kinesin-2 Controls the Motility of RAB5 Endosomes and Their Association with the Spindle in Mitosis.International journal of molecular sciences · 2018Article
- α5β1 integrin trafficking and Rac activation are regulated by APPL1 in a Rab5-dependent manner to inhibit cell migration.Journal of cell science · 2018Article
- A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin.Molecular biology of the cell · 2017Article
- Spatial control of Shoc2-scaffold-mediated ERK1/2 signaling requires remodeling activity of the ATPase PSMC5.Journal of cell science · 2015Article
- Article
- The relevance of cell type- and tumor zone-specific VEGFR-2 activation in locally advanced colon cancer.Journal of experimental & clinical cancer research : CR · 2015Article
- Transgenic plants as low-cost platform for chemotherapeutic drugs screening.International journal of molecular sciences · 2015Article
- Secreted protein acidic and rich in cysteine internalization and its age-related alterations in skeletal muscle progenitor cells.Aging cell · 2014Article
- A ligand-independent VEGFR2 signaling pathway limits angiogenic responses in diabetes.Science signaling · 2014Article
- Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2 (SOCS2) is a new player.Frontiers in molecular neuroscience · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endocytosis and recycling are essential components of the wiring enabling cells to perceive extracellular signals and transduce them in a temporally and spatially controlled fashion, directly influencing not only the duration and intensity of the signaling output, but also their correct location. Here, we will discuss key experimental evidence that support how different internalization routes, the generation of diverse endomembrane platforms, and cycles of internalization and recycling ensure polarized compartmentalization of signals, regulating a number of physiological and pathologically-relevant processes in which the resolution of spatial information is vital for their execution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.