ReviewJournal of pediatric urology2009
Controversies in the management of vesicoureteral reflux: the rationale for the RIVUR study.
Review in Journal of pediatric urology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00405704 (Randomized Intervention for Children With Vesicoureteral Reflux), which is not on this map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR)
Who cites it
13 citing papers in PubMed, 48 citations in OpenAlex.
- Does the presence of non-refluxing hydroureter impact the management and outcome of high-grade hydronephrosis?Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2020Article
- Controversies Regarding Management of Vesico-ureteric Reflux.Indian journal of pediatrics · 2017Review
- Imaging studies and biomarkers to detect clinically meaningful vesicoureteral reflux.Investigative and clinical urology · 2017Review
- Insignificant impact of VUR on the progression of CKD in children with CAKUT.Pediatric nephrology (Berlin, Germany) · 2016Article
- Childhood vesicoureteral reflux studies: registries and repositories sources and nosology.Journal of pediatric urology · 2013Review
- The impact of vesicoureteral reflux treatment on the incidence of urinary tract infection.Pediatric nephrology (Berlin, Germany) · 2012Review
- Radiographic evaluation of children with febrile urinary tract infection: bottom-up, top-down, or none of the above?Advances in urology · 2012Article
- Patients with a history of infection and voiding dysfunction are at risk for recurrence after successful endoscopic treatment of vesico ureteral reflux and deserve long-term follow up.Urology annals · 2012Article
- [Vesicoureteral reflux: diagnostics and therapy].Der Urologe. Ausg. A · 2011Review
- Learning from history or the rationale for considering surgical correction of vesicoureteral reflux.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2010Article
- Medical versus surgical management for vesicoureteric reflux: the case for medical management.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2010Article
- Surgical intervention in children with vesicoureteric reflux: are we intervening too late?Pediatric surgery international · 2010Article
- Urinary tract infections in children: recommendations for antibiotic prophylaxis and evaluation. An evidence-based approach.Current urology reports · 2010Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
unlabelledThe current management of vesicoureteral reflux (VUR) focuses on the prevention of urinary tract infections (UTI), with curative surgery being limited to those children that fail conservative measures. This is based on the assumption that UTIs are preventable with the use of prophylatic antibiotics, leading to reduction of renal scarring, and the possibility that VUR in children can resolve spontaneously.
methodsReview of the recent literature has demonstrated a growing concern that antibiotic prophylaxis may not lead to prevention of UTIs. Additionally, data indicate that renal scarring may not be preventable with antibiotic prophylaxis or even surgical correction of VUR. An overview of all of the current controversies is presented in this paper.
resultsDoes antibiotic prophylaxis lead to reduction in UTIs in children with VUR? To address this question, the National Institutes of Health have developed a randomized placebo-controlled study of children with VUR (the RIVUR Study), identified following the development of a UTI.
conclusionsThere are far reaching consequences of the results of the RIVUR Study. If antibiotic prophylaxis does not prevent UTI in children with VUR, or lead to reduction in renal scarring, does identification of VUR provide any benefits? Perhaps appropriate treatment of UTI may be all that is necessary for preserving renal function. Final answers will have to wait until the completion of this study.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.