ArticleCritical care (London, England)2009
Changes in serum adiponectin concentrations in critical illness: a preliminary investigation.
Article in Critical care (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 95 citations in OpenAlex.
- Increased plasma vaspin concentration in patients with sepsis: an exploratory examination.Biochemia medica · 2015Trial
- Plasma adiponectin and mortality in critically ill subjects with acute respiratory failure.Critical care medicine · 2010Trial
- Harnessing adiponectin for sepsis: current knowledge, clinical insights and future therapies.Critical care (London, England) · 2025Review
- Serum Adiponectin Is Elevated in Critically Ill Patients with Liver Disease and Associated with Decreased Overall Survival.Biomedicines · 2024Article
- Serum Adiponectin Predicts COVID-19 Severity.Biomedicines · 2024Article
- Exploring the Relationship between Plasma Adiponectin, Gender, and Underlying Diseases in Severe Illness.Biomedicines · 2023Article
- Serum adiponectin-levels are predictive of probable posttraumatic stress disorder in women.Neurobiology of stress · 2022Article
- Prospective Association of Circulating Adipokines with Cardiometabolic Risk Profile Among Women: The Rape Impact Cohort Evaluation Study.Women's health reports (New Rochelle, N.Y.) · 2022Article
- Serum Perilipin 2 (PLIN2) Predicts Multiple Organ Dysfunction in Critically Ill Patients.Biomedicines · 2021Article
- Plasma as a resuscitation fluid for volume-depleted shock: Potential benefits and risks.Transfusion · 2021Review
- Apoptosis of hematopoietic progenitor-derived adipose tissue-resident macrophages contributes to insulin resistance after myocardial infarction.Science translational medicine · 2020Article
- Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work.International journal of molecular sciences · 2020Review
- Exploring the New Horizon of AdipoQ in Obesity-Related Alzheimer's Dementia.Frontiers in physiology · 2020Review
- The Role of Adipose Tissue and Adipokines in Sepsis: Inflammatory and Metabolic Considerations, and the Obesity Paradox.Current obesity reports · 2019Review
- The Role of Adipokines as Circulating Biomarkers in Critical Illness and Sepsis.International journal of molecular sciences · 2019Review
- Secret talk between adipose tissue and central nervous system via secreted factors-an emerging frontier in the neurodegenerative research.Journal of neuroinflammation · 2016Review
- Alcohol's Burden on Immunity Following Burn, Hemorrhagic Shock, or Traumatic Brain Injury.Alcohol research : current reviews · 2015Review
- Lipopolysaccharide induces a downregulation of adiponectin receptors in-vitro and in-vivo.PeerJ · 2015Article
- Year in review 2013: Critical Care--metabolism.Critical care (London, England) · 2014Review
- Inflammation biomarkers and delirium in critically ill patients.Critical care (London, England) · 2014Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAdiponectin plays an important role in the regulation of tissue inflammation and insulin sensitivity. Perturbations in adiponectin concentration have been associated with obesity and the metabolic syndrome. Data on adiponectin pathophysiology in critical illness are limited.
methodsTwenty three critically ill patients (9 severe sepsis, 7 burns, 7 trauma). Adiponectin assays on Days 3 (D3) and 7 (D7). Simultaneous, cortisol, cortisone and CRP measurements. Data from 16 historical controls were used for comparison.
resultsThe mean plasma adiponectin concentration for the ICU cohort on D3 and D7 were not significantly different (4.1 +/- 1.8 and 5.0 +/- 3.3 mcg/ml respectively, P = 0.38). However, these were significantly lower than the mean plasma adiponectin in the control population (8.78 +/- 3.81 mcg/ml) at D3 (P < 0.0001) and D7 (P = 0.002). Plasma adiponectin showed a strong correlation with plasma cortisol in the ICU group on both D3 (R2 = 0.32, P < 0.01) and D7 (R2 = 0.64, 0.001). There was an inverse correlation between plasma adiponectin and CRP on D7, R = -0.35.
conclusionsIn this preliminary study, critical illness was associated with lower adiponectin concentrations as compared with controls. A significant relationship between plasma cortisol and adiponectin in critically ill patients was evident, both during the early and late phases. These data raise the possibility that adiponectin may play a part in the inflammatory response in patients with severe illness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.