ArticleBMC developmental biology2009
Developmental changes in the expression of creatine synthesizing enzymes and creatine transporter in a precocial rodent, the spiny mouse.
Article in BMC developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 63 citations in OpenAlex.
- Metabolism and homeostasis of energy in trophoblast cells of the placenta: from development to disease†.Biology of reproduction · 2026Review
- Metabolic and immune links between sarcopenia and liver disease.World journal of hepatology · 2025Article
- [Scientific reports · 2025Article
- The Umbilical Cord Creatine Flux and Time Course of Human Milk Creatine across Lactation.Nutrients · 2024Article
- Creatine and pregnancy outcomes, a prospective cohort study in low-risk pregnant women: study protocol.BMJ open · 2019Article
- UNICORN Babies: Understanding Circulating and Cerebral Creatine Levels of the Preterm Infant. An Observational Study Protocol.Frontiers in physiology · 2019Article
- Creatine supplementation to total parenteral nutrition improves creatine status and supports greater liver and kidney protein synthesis in neonatal piglets.Pediatric research · 2018Article
- A Mouse Model of Creatine Transporter Deficiency Reveals Impaired Motor Function and Muscle Energy Metabolism.Frontiers in physiology · 2018Article
- De novo transcriptome assembly for the spiny mouse (Acomys cahirinus).Scientific reports · 2017Article
- Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges.Frontiers in cellular neuroscience · 2017Review
- Creatine kinase in ischemic and inflammatory disorders.Clinical and translational medicine · 2016Review
- The Biology and Husbandry of the African Spiny Mouse (Acomys cahirinus) and the Research Uses of a Laboratory Colony.Journal of the American Association for Laboratory Animal Science : JAALAS · 2016Article
- In vivo longitudinal proton magnetic resonance spectroscopy on neonatal hypoxic-ischemic rat brain injury: Neuroprotective effects of acetyl-L-carnitine.Magnetic resonance in medicine · 2015Article
- Maternal creatine homeostasis is altered during gestation in the spiny mouse: is this a metabolic adaptation to pregnancy?BMC pregnancy and childbirth · 2015Article
- Creatine supplementation during pregnancy: summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy.BMC pregnancy and childbirth · 2014Review
- Creatine transporter (SLC6A8) knockout mice display an increased capacity for in vitro creatine biosynthesis in skeletal muscle.Frontiers in physiology · 2014Article
- Maternal dietary creatine supplementation does not alter the capacity for creatine synthesis in the newborn spiny mouse.Reproductive sciences (Thousand Oaks, Calif.) · 2013Article
- Early dynamic transcriptomic changes during preoperative radiotherapy in patients with rectal cancer: a feasibility study.World journal of gastroenterology · 2013Article
- Cyclocreatine treatment improves cognition in mice with creatine transporter deficiency.The Journal of clinical investigation · 2012Article
- Creatine and guanidinoacetate transport at blood-brain and blood-cerebrospinal fluid barriers.Journal of inherited metabolic disease · 2012Review
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCreatine synthesis takes place predominately in the kidney and liver via a two-step process involving AGAT (L-arginine:glycine amidinotransferase) and GAMT (guanidinoacetate methyltransferase). Creatine is taken into cells via the creatine transporter (CrT), where it plays an essential role in energy homeostasis, particularly for tissues with high and fluctuating energy demands. Very little is known of the fetal requirement for creatine and how this may change with advancing pregnancy and into the early neonatal period. Using the spiny mouse as a model of human perinatal development, the purpose of the present study was to comprehensively examine the development of the creatine synthesis and transport systems.
resultsThe estimated amount of total creatine in the placenta and brain significantly increased in the second half of pregnancy, coinciding with a significant increase in expression of CrT mRNA. In the fetal brain, mRNA expression of AGAT increased steadily across the second half of pregnancy, although GAMT mRNA expression was relatively low until 34 days gestation (term is 38-39 days). In the fetal kidney and liver, AGAT and GAMT mRNA and protein expression were also relatively low until 34-37 days gestation. Between mid-gestation and term, neither AGAT or GAMT mRNA or protein could be detected in the placenta.
conclusionOur results suggest that in the spiny mouse, a species where, like the human, considerable organogenesis occurs before birth, there appears to be a limited capacity for endogenous creatine synthesis until approximately 0.9 of pregnancy. This implies that a maternal source of creatine, transferred across the placenta, may be essential until the creatine synthesis and transport system matures in preparation for birth. If these results also apply to the human, premature birth may increase the risk of creatine deficiency.
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