ArticleASN neuro2009
MyD88 expression by CNS-resident cells is pivotal for eliciting protective immunity in brain abscesses.
Article in ASN neuro, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Gut Microbiota in Heart Failure-The Role of Inflammation.Biomedicines · 2025Review
- MyD88 in lung resident cells governs airway inflammatory and pulmonary function responses to organic dust treatment.Respiratory research · 2015Article
- Ventricular shunt infections: immunopathogenesis and clinical management.Journal of neuroimmunology · 2014Review
- Critical role for the AIM2 inflammasome during acute CNS bacterial infection.Journal of neurochemistry · 2014Article
- Brain abscess: Current management.Journal of neurosciences in rural practice · 2013Review
- Article
- Toll-like receptor (TLR) and inflammasome actions in the central nervous system.Trends in immunology · 2012Review
- Article
- Th1 and Th17 cells regulate innate immune responses and bacterial clearance during central nervous system infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- FACS purification of immunolabeled cell types from adult rat brain.Journal of neuroscience methods · 2012Article
- Toll-like receptor 2 (TLR2)-TLR9 crosstalk dictates IL-12 family cytokine production in microglia.Glia · 2012Article
- Review: apoptotic mechanisms in bacterial infections of the central nervous system.Frontiers in immunology · 2012Article
- Central nervous system fibrosis is associated with fibrocyte-like infiltrates.The American journal of pathology · 2011Article
- Inflammasome activation and IL-1β/IL-18 processing are influenced by distinct pathways in microglia.Journal of neurochemistry · 2011Article
- Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential.Clinical science (London, England : 1979) · 2011Review
- Roles of Toll-like receptor 2 (TLR2) and superantigens on adaptive immune responses during CNS staphylococcal infection.Brain, behavior, and immunity · 2011Article
- MyD88 is pivotal for immune recognition of Citrobacter koseri and astrocyte activation during CNS infection.Journal of neuroinflammation · 2011Article
- FACS identifies unique cocaine-induced gene regulation in selectively activated adult striatal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia.Infection and immunity · 2010Article
- Microglia in infectious diseases of the central nervous system.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
MyD88 KO (knockout) mice are exquisitely sensitive to CNS (central nervous system) infection with Staphylococcus aureus, a common aetiological agent of brain abscess, exhibiting global defects in innate immunity and exacerbated tissue damage. However, since brain abscesses are typified by the involvement of both activated CNS-resident and infiltrating immune cells, in our previous studies it has been impossible to determine the relative contribution of MyD88-dependent signalling in the CNS compared with the peripheral immune cell compartments. In the present study we addressed this by examining the course of S. aureus infection in MyD88 bone marrow chimaera mice. Interestingly, chimaeras where MyD88 was present in the CNS, but not bone marrow-derived cells, mounted pro-inflammatory mediator expression profiles and neutrophil recruitment equivalent to or exceeding that detected in WT (wild-type) mice. These results implicate CNS MyD88 as essential in eliciting the initial wave of inflammation during the acute response to parenchymal infection. Microarray analysis of infected MyD88 KO compared with WT mice revealed a preponderance of differentially regulated genes involved in apoptotic pathways, suggesting that the extensive tissue damage characteristic of brain abscesses from MyD88 KO mice could result from dysregulated apoptosis. Collectively, the findings of the present study highlight a novel mechanism for CNS-resident cells in initiating a protective innate immune response in the infected brain and, in the absence of MyD88 in this compartment, immunity is compromised.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.