ArticleEnvironmental health and preventive medicine2008
Epigenetics in mood disorders.
Article in Environmental health and preventive medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
28 citing papers in PubMed, 81 citations in OpenAlex.
- Circulating long noncoding RNA: New frontiers in biomarker research for mood disorders.Genomic psychiatry : advancing science from genes to society · 2025Article
- Deciphering the epigenetic role of long non-coding RNAs in mood disorders: Focus on human brain studies.Clinical and translational medicine · 2025Review
- Understanding immune system dysfunction and its context in mood disorders: psychoneuroimmunoendocrinology and clinical interventions.Military Medical Research · 2024Review
- Epigenetics, Nutrition, and the Brain: Improving Mental Health through Diet.International journal of molecular sciences · 2024Review
- Probiotics and Commensal Bacteria Metabolites Trigger Epigenetic Changes in the Gut and Influence Beneficial Mood Dispositions.Microorganisms · 2023Review
- Prenatal stress induced chromatin remodeling and risk of psychopathology in adulthood.International review of neurobiology · 2021Article
- Bipolar offspring and mothers: interactional challenges at infant age 3 and 12 months-a developmental pathway to enhanced risk?International journal of bipolar disorders · 2020Article
- DNA Methyltransferases in Depression: An Update.Frontiers in psychiatry · 2020Review
- Molecules of Silence: Effects of Meditation on Gene Expression and Epigenetics.Frontiers in psychology · 2020Review
- Exposure to childhood abuse is associated with human sperm DNA methylation.Translational psychiatry · 2018Article
- Association between reduced white matter integrity in the corpus callosum and serotonin transporter gene DNA methylation in medication-naive patients with major depressive disorder.Translational psychiatry · 2016Article
- Psychological factors and DNA methylation of genes related to immune/inflammatory system markers: the VA Normative Aging Study.BMJ open · 2016Article
- Metabotropic Glutamate 2/3 Receptors and Epigenetic Modifications in Psychotic Disorders: A Review.Current neuropharmacology · 2016Review
- Early Life Stress, Nicotinic Acetylcholine Receptors and Alcohol Use Disorders.Brain sciences · 2015Review
- Role of hippocampus mitogen-activated protein kinase phosphatase-1 mRNA expression and DNA methylation in the depression of the rats with chronic unpredicted stress.Cellular and molecular neurobiology · 2015Article
- Pharmacoepigenetics of depression: no major influence of MAO-A DNA methylation on treatment response.Journal of neural transmission (Vienna, Austria : 1996) · 2015Article
- The developmental basis of epigenetic regulation of HTR2A and psychiatric outcomes.Journal of cellular biochemistry · 2014Review
- Serotonin transporter gene methylation is associated with hippocampal gray matter volume.Human brain mapping · 2014Article
- Hypothalamic-pituitary-adrenal axis dysfunction and illness progression in bipolar disorder.The international journal of neuropsychopharmacology · 2014Article
- Epigenetics and the war on mental illness.Molecular psychiatry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression develops as an interaction between stress and an individual's vulnerability to stress. The effect of early life stress and a gene-environment interaction may play a role in the development of stress vulnerability as a risk factor for depression. The epigenetic regulation of the promoter of the glucocorticoid receptor gene has been suggested as a molecular basis of such stress vulnerability. It has also been suggested that antidepressive treatment, such as antidepressant medication and electroconvulsive therapy, may be mediated by histone modification on the promoter of the brain-derived neurotrophic factor gene. Clinical genetic studies in bipolar disorder suggest the role of genomic imprinting, although no direct molecular evidence of this has been reported. The role of DNA methylation in mood regulation is indicated by the antimanic effect of valproate, a histone deacetylase inhibitor, and the antidepressive effect of S-adenosyl methionine, a methyl donor in DNA methylation. Studies of postmortem brains of patients have implicated altered DNA meA methylation of the promoter region of membrane-bound catechol-O-methyltransferase in bipolar disorder. An altered DNA methylation status of PPIEL (peptidylprolyl isomerase E-like) was found in a pair of monozygotic twins discordant for bipolar disorder. Hypomethylation of PPIEL was also found in patients with bipolar II disorder in a case control analysis. These fragmentary findings suggest the possible role of epigenetics in mood disorders. Further studies of epigenetics in mood disorders are warranted.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.