ArticleEnvironmental health and preventive medicine2008
DNA methylation: a marker for carcinogen exposure and cancer risk.
Article in Environmental health and preventive medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Pooled it
- Translational value of IDH1 and DNA methylation biomarkers in diagnosing lung cancers: a novel diagnostic panel of stage and histology-specificity.Journal of translational medicine · 2019Trial
- Relationship between LINE-1 hypomethylation and Helicobacter pylori infection in gastric mucosae.Medical oncology (Northwood, London, England) · 2015Trial
- PMEnvironmental health and preventive medicine · 2020Article
- Epigenetic Mechanisms and Events in Gastric Cancer-Emerging Novel Biomarkers.Pathology oncology research : POR · 2018Review
- Article
- Methylation status of theOncology letters · 2016Article
- Braf, Kras and Helicobacter pylori epigenetic changes-associated chronic gastritis in Egyptian patients with and without gastric cancer.World journal of microbiology & biotechnology · 2016Article
- Article
- Aberrant Epigenetic Modifications of LPHN2 Function as a Potential Cisplatin-Specific Biomarker for Human Gastrointestinal Cancer.Cancer research and treatment · 2016Article
- Epigenetic alterations in gastric cancer (Review).Molecular medicine reports · 2015Review
- Helicobacter pylori-related chronic gastritis as a risk factor for colonic neoplasms.World journal of gastroenterology · 2014Review
- Elevated risk of recurrent colorectal neoplasia withMolecular and clinical oncology · 2013Article
- Environmental toxicants, epigenetics, and cancer.Advances in experimental medicine and biology · 2013Review
- Characterization of DNA hypermethylation in two cases of peritoneal mesothelioma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Methylation analysis of cancer-related genes in non-neoplastic cells from patients with oral squamous cell carcinoma.Molecular biology reports · 2011Article
- Role of DNA methylation in head and neck cancer.Clinical epigenetics · 2011Article
- Novel risk markers for gastric cancer screening: Present status and future prospects.World journal of gastrointestinal endoscopy · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancers arise as a consequence of multiple genetic and epigenetic alterations. Many genes aberrantly methylated in cancers have been identified in recent years, and their use in cancer diagnosis and therapy is currently under investigation. During our genome-wide screening for a novel tumor-suppressor gene in gastric cancers, we found that only a small amount of aberrant methylation was present, even in non-cancerous gastric mucosae. A subsequent large-scale analysis of the gastric mucosae of healthy individuals and gastric cancer patients using quantitative methylation-specific PCR (qMSP) revealed that Helicobacter pylori infection potently induced aberrant DNA methylation in non-cancerous gastric mucosae and that these high methylation levels can decrease following cessation of the H. pylori infection. Helicobacter pylori infection induced the methylation of specific genes among 48 genes that can be methylated in gastric cancer cell lines. Most importantly, the methylation levels in the gastric mucosae of individuals without H. pylori infection correlated with their risk of gastric cancer. These findings show that a field for cancerization is formed by H. pylori infection and that this field can be measured using DNA methylation as a marker. The concept of an "epigenetic field for cancerization" has been also demonstrated for colon and breast cancers, and it is possibly present for other cancers and other diseases. Applied knowledge of epigenetic changes in human diseases has now started to make an impact on the prevention, diagnostics, and therapeutics of these diseases.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.