ArticleJournal of molecular evolution2009
Genome desertification in eutherians: can gene deserts explain the uneven distribution of genes in placental mammalian genomes?
Article in Journal of molecular evolution, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Patterns in the genome.Heredity · 2019Review
- Coding sequence density estimation via topological pressure.Journal of mathematical biology · 2015Article
- The footprint of metabolism in the organization of mammalian genomes.BMC genomics · 2012Article
- DNA double-strand breaks induced by high NaCl occur predominantly in gene deserts.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
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4 authors.
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Abstract
The evolution of genome size as well as structure and organization of genomes belongs among the key questions of genome biology. Here we show, based on a comparative analysis of 30 genomes, that there is generally a tight correlation between the number of genes per chromosome and the length of the respective chromosome in eukaryotic genomes. The surprising exceptions to this pattern are placental mammalian genomes. We identify the number and, more importantly, the uneven distribution of gene deserts among chromosomes, i.e., long (>500 kb) stretches of DNA that do not encode for genes, as the main contributing factor for the observed anomaly of eutherian genomes. Gene-rich placental mammalian chromosomes have smaller proportions of gene deserts and vice versa. We show that the uneven distribution of gene deserts is a derived character state of eutherians. The functional and evolutionary significance of this particular feature of eutherian genomes remains to be explained.
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