ArticlePlanta2009
A branched-chain aminotransferase may regulate hormone levels by affecting KNOX genes in plants.
Article in Planta, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Branched-chain amino acid catabolism initiates volatile synthesis in Gentiana triflora.Planta · 2025Article
- The branched-chain amino acid-related isoleucic acid: recent research advances.Plant biology (Stuttgart, Germany) · 2025Review
- Regulation of meristem and hormone function revealed through analysis of directly-regulated SHOOT MERISTEMLESS target genes.Scientific reports · 2025Article
- An overview of branched-chain amino acid aminotransferases: functional differences between mitochondrial and cytosolic isozymes in yeast and human.Applied microbiology and biotechnology · 2021Review
- Jasmonates-Mediated Rewiring of Central Metabolism Regulates Adaptive Responses.Plant & cell physiology · 2019Article
- The overexpression of cucumber (Cucumis sativus L.) genes that encode the branched-chain amino acid transferase modulate flowering time in Arabidopsis thaliana.Plant cell reports · 2019Article
- Article
- Genome-wide analysis of branched-chain amino acid levels in Arabidopsis seeds.The Plant cell · 2013Article
- Crystal structures of complexes of the branched-chain aminotransferase from Deinococcus radiodurans with α-ketoisocaproate and L-glutamate suggest the radiation resistance of this enzyme for catalysis.Journal of bacteriology · 2012Article
- New insights in the sugarcane transcriptome responding to drought stress as revealed by superSAGE.TheScientificWorldJournal · 2012Article
- The genetic architecture of branched-chain amino acid accumulation in tomato fruits.Journal of experimental botany · 2011Article
- Characterization of the branched-chain amino acid aminotransferase enzyme family in tomato.Plant physiology · 2010Article
- Branched-Chain Amino Acid Metabolism in Arabidopsis thaliana.The arabidopsis book · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Branched-chain amino acid transaminases (BCATs) play a crucial role in the metabolic pathway of leucine, isoleucine and valine by catalyzing the last step of synthesis and/or the initial step of degradation of these amino acids. In this study, we characterized a new BCAT from Nicotiana benthamiana (NbBCAT, GeneBank accession No. EU194916), the deduced amino acid sequence of which exhibits a very high percentage of identity to the homologous enzymes from Solanum tuberosum (StBCAT-2, 91.5%) and Arabidopsis thaliana (AtBCAT1-6, 56.4-68.6%). Complementation experiment using a Deltabat1/Deltabat2 double knockout yeast strain system demonstrated enzymatic activities for NbBCAT. Ectopically expressed NbBCAT::green fluorescence fusion protein was targeted predominantly to the chloroplasts in tobacco protoplasts. The highest levels of NbBCAT transcripts were found in open flowers as well as in young leaves. Virus-induced gene silencing of NbBCAT resulted in abnormal leaf development and loss of apical dominance. In NbBCAT-silenced plants, two KNOTTED1-type genes, NTH15 and NTH23, were upregulated. This was accompanied by various hormone changes, as a result of transcriptional regulation of gibberellin 20-oxidase (Ntc12) and adenosine phosphate isopentenyltransferase. The transcript levels of NbBCAT could also be repressed by hormone treatment. These results suggest that NbBCAT, an enzyme in the branched-chain amino acid metabolic pathway, may be involved in the regulation of endogenous hormones by its effect on KNOX genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.