ArticleLab on a chip2009
Dynamic bioprocessing and microfluidic transport control with smart magnetic nanoparticles in laminar-flow devices.
Article in Lab on a chip, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Physicochemical Stimulus-Responsive Systems Targeted with Antibody Derivatives.Current molecular medicine · 2024Review
- Exosome Processing and Characterization Approaches for Research and Technology Development.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Temperature-Responsive Magnetic Nanoparticles for Enabling Affinity Separation of Extracellular Vesicles.ACS applied materials & interfaces · 2018Article
- A Stimuli-Responsive, Binary Reagent System for Rapid Isolation of Protein Biomarkers.Analytical chemistry · 2016Article
- Human Immunodeficiency Virus (HIV) Separation and Enrichment via the Combination of Antiviral Lectin Recognition and a Thermoresponsive Reagent System.Pharmaceutical research · 2016Article
- Microfluidic cell sorting: a review of the advances in the separation of cells from debulking to rare cell isolation.Lab on a chip · 2015Review
- Stimuli-responsive reagent system for enabling microfluidic immunoassays with biomarker purification and enrichment.Bioconjugate chemistry · 2015Article
- Room Temperature Co-Precipitation Synthesis of Magnetite Nanoparticles in a Large pH Window with Different Bases.Materials (Basel, Switzerland) · 2013Article
- A photoinduced nanoparticle separation in microchannels via pH-sensitive surface traps.Langmuir : the ACS journal of surfaces and colloids · 2013Article
- A smart hydrogel-based time bomb triggers drug release mediated by pH-jump reaction.Science and technology of advanced materials · 2012Article
- Novel temperature-responsive polymer brushes with carbohydrate residues facilitate selective adhesion and collection of hepatocytes.Science and technology of advanced materials · 2012Article
- Multiplexed enrichment and detection of malarial biomarkers using a stimuli-responsive iron oxide and gold nanoparticle reagent system.ACS nano · 2012Article
- Spinning magnetic trap for automated microfluidic assay systems.Lab on a chip · 2012Article
- 2010 Panel on the biomaterials grand challenges.Journal of biomedical materials research. Part A · 2011Article
- Mixed stimuli-responsive magnetic and gold nanoparticle system for rapid purification, enrichment, and detection of biomarkers.Bioconjugate chemistry · 2010Article
- Microfluidics in macro-biomolecules analysis: macro inside in a nano world.Analytical and bioanalytical chemistry · 2010Review
- "Smart" diblock copolymers as templates for magnetic-core gold-shell nanoparticle synthesis.Nano letters · 2010Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
In the absence of applied forces, the transport of molecules and particulate reagents across laminar flowstreams in microfluidic devices is dominated by the diffusivities of the transported species. While the differential diffusional properties between smaller and larger diagnostic targets and reagents have been exploited for bioseparation and assay applications, there are limitations to methods that depend on these intrinsic size differences. Here a new strategy is described for exploiting the sharply reversible change in size and magnetophoretic mobility of "smart" magnetic nanoparticles (mNPs) to perform bioseparation and target isolation under continuous flow processing conditions. The isolated 5 nm mNPs do not exhibit significant magnetophoretic velocities, but do exhibit high magnetophoretic velocities when aggregated by the action of a pH-responsive polymer coating. A simple external magnet is used to magnetophorese the aggregated mNPs that have captured a diagnostic target from a lower pH laminar flowstream (pH 7.3) to a second higher pH flowstream (pH 8.4) that induces rapid mNP disaggregation. In this second dis-aggregated state and flowstream, the mNPs continue to flow past the magnet rather than being immobilized at the channel surface near the magnet. This stimuli-responsive reagent system has been shown to transfer 81% of a model protein target from an input flowstream to a second flowstream in a continuous flow H-filter device.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.