ArticleSaudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association2008
Assessment of thrombophilic abnormalities during the active state of inflammatory bowel disease.
Article in Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Abnormal platelet parameters in inflammatory bowel disease: a systematic review and meta-analysis.BMC gastroenterology · 2024Pooled it
- Factor V Leiden and inflammatory bowel disease: a systematic review and meta-analysis.Journal of gastroenterology · 2011Pooled it
- Levels of TAFI, TFPI and ADAMTS-13 in inflammatory bowel disease.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019Article
- Prevalence, significance and predictive value of antiphospholipid antibodies in Crohn's disease.World journal of gastroenterology · 2015Article
- Venous thrombosis and prothrombotic factors in inflammatory bowel disease.World journal of gastroenterology · 2014Review
- Factor v leiden and inflammation.Thrombosis · 2012Article
- Epidemiology of activated protein C resistance and factor v leiden mutation in the mediterranean region.Mediterranean journal of hematology and infectious diseases · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
BACKGROUND/
aimsThromboembolic disease has been recognized as a complication of inflammatory bowel disease (IBD). The relative contributions of inherited or acquired thrombophilia and the inflammatory response to the mechanism of this tendency are unclear. Thrombotic events are more common in active disease although significant numbers also occur spontaneously. The aim of this study was to investigate common thrombophilic markers in patients with active IBD.
methodsTwenty-six patients with IBD who had active disease, and 40 sex- and age-matched non-IBD patients were recruited into the study. For all the subjects, complete blood counts, C-reactive protein levels, erythrocyte sedimentation rate, International normalized ratio, activated partial thromboplastin time, and levels of lupus anticoagulant, anticardiolipin antibodies (ACA IgG), proteins C and S, antithrombin-III (AT-III), and factor V were measured.
resultsThe International normalized ratio, activated partial thromboplastin time, and levels of proteins C and S were comparable between the two groups. However, antithrombin-III levels were significantly lower in the IBD group as compared with that in the healthy control group (P < 0.001). ACA IgG was detected in one patient in the IBD group. Factor V Leiden mutation was present in 3.8% of the patients in the IBD group, whereas the prevalence was 2.5% in the control group. Significantly elevated platelet counts were observed in patients with active Crohn's disease compared with that in the control group (P < 0.001), but they were not significantly increased in active ulcerative colitis (P = 0.231).
conclusionsThe present study failed to establish a strong association between the common thrombophilic markers and the active clinical course of IBD, with the exception of high platelet counts and lower levels of AT-III in the IBD group as compared with those in the control group. All other parameters of thrombophilia were comparable between the two groups.
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