ArticleJournal of psychiatry & neuroscience : JPN2009
Alcohol dependence-related increase of glial cell density in the anterior cingulate cortex of suicide completers.
Article in Journal of psychiatry & neuroscience : JPN, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Glial Markers of Suicidal Behavior in the Human Brain-A Systematic Review of Postmortem Studies.International journal of molecular sciences · 2024Pooled it
- Joint and distinct neural structure and function deficits in major depressive disorder with suicidality: a multimodal meta-analysis of MRI studies.Journal of psychiatry & neuroscience : JPNPooled it
- Pathophysiology in cortico-amygdala circuits and excessive aversion processing: the role of oligodendrocytes and myelination.Brain communications · 2024Review
- Brain Gene Expression Pattern of Subjects with Completed Suicide and Comorbid Substance Use Disorder.Molecular neuropsychiatry · 2019Article
- Neuropathology of suicide: recent findings and future directions.Molecular psychiatry · 2017Review
- Neuropathology of mood disorders: do we see the stigmata of inflammation?Translational psychiatry · 2016Review
- Reduced GABA neuron density in auditory cerebral cortex of subjects with major depressive disorder.Journal of chemical neuroanatomy · 2016Article
- Basolateral amygdala volume and cell numbers in major depressive disorder: a postmortem stereological study.Brain structure & function · 2016Article
- Brain tissue compartment density estimated using diffusion-weighted MRI yields tissue parameters consistent with histology.Human brain mapping · 2015Article
- Astrocytic abnormalities and global DNA methylation patterns in depression and suicide.Molecular psychiatry · 2015Article
- Increased doublecortin (DCX) expression and incidence of DCX-immunoreactive multipolar cells in the subventricular zone-olfactory bulb system of suicides.Frontiers in neuroanatomy · 2015Article
- Morphometric characterization of microglial phenotypes in human cerebral cortex.Journal of neuroinflammation · 2014Article
- Glial abnormalities in substance use disorders and depression: does shared glutamatergic dysfunction contribute to comorbidity?The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2014Review
- Astrocytic hypertrophy in anterior cingulate white matter of depressed suicides.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSuicide is the most serious consequence of major depressive disorder (MDD). Although the anterior cingulate cortex (ACC; Brodmann area [BA] 24) has been increasingly investigated for its role in the etiology of MDD, there is surprisingly very little information about the possible implication of this brain region in suicide. We hypothesized that changes in BA24 cell densities occur in depressed individuals who commit suicide, possibly reflecting an altered state of cortical plasticity that is thought to occur in depression.
methodsWe investigated cell densities and sizes in BA24 among suicide completers and matched sudden-death controls. We examined a 1-cm(3) tissue block from BA24a of the supracallosal ACC in 26 human postmortem brain specimens (13 depressed individuals who committed suicide and 13 controls). We assessed neuronal and glial cell densities as well as neuronal soma sizes in the upper and lower cortical layers using optical fractionator and nucleator 3-dimensional stereological probes.
resultsGlial densities, neuronal densities and soma sizes measured in BA24a did not differ significantly between controls and suicide completers. Secondary analyses showed a significant and robust increase in glial cell densities in BA24a of alcohol-dependent depressed suicide completers compared with depressed suicide completers who were not alcohol-dependent (38%) and, to a lesser extent, controls (30%). LIMITATIONS: Our study, conducted with tissue samples from men only, made use of a nonspecific stain that does not distinguish between neuronal or glial cell subtypes. Furthermore, the quantitative analysis concerned upper and lower cortical contours rather than individual cortical layers.
conclusionOur results indicate that in BA24, glial density, neuronal density and soma size are not affected in MDD and suicide. They also suggest that alcohol dependence has an important influence on glial densities in this key limbic structure.
Indexed as
Identifiers
19568479PMC2702445What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.