ArticleOrganogenesis2009
Xenotransplantation as a model of integrated, multidisciplinary research.
Article in Organogenesis, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- A sustainable approach to derive sheep corneal scaffolds from stored slaughterhouse waste.Regenerative medicine · 2024Article
- Ethical and legislative advances in xenotransplantation for clinical translation: focusing on cardiac, kidney and islet cell xenotransplantation.Frontiers in immunology · 2024Review
- Dextromethorphan Exhibits Anti-Inflammatory and Immunomodulatory Effects in a Murine Model: Therapeutic Implication in Psoriasis.Life (Basel, Switzerland) · 2022Article
- DNA repair and replication links to pluripotency and differentiation capacity of pig iPS cells.PloS one · 2017Article
- Concise Review: Markers for Assessing Human Stem Cell-Derived Implants as β-Cell Replacement in Type 1 Diabetes.Stem cells translational medicine · 2016Review
- Apoptosis in Porcine Pluripotent Cells: From ICM to iPSCs.International journal of molecular sciences · 2016Review
- Quantitative analysis of porcine endogenous retroviruses in different organs of transgenic pigs generated for xenotransplantation.Current microbiology · 2013Article
- Telomere reprogramming and maintenance in porcine iPS cells.PloS one · 2013Article
- Association of telomere instability with senescence of porcine cells.BMC cell biology · 2012Article
- In vitro-growth and Gene Expression of Porcine Preantral Follicles Retrieved by Different Protocols.Asian-Australasian journal of animal sciences · 2012Article
- Encapsulated cell grafts to treat cellular deficiencies and dysfunction.Critical reviews in biomedical engineering · 2011Review
- General overview of the Sixth International Symposium on Stem Cell Therapy and Cardiovascular Innovations.Journal of cardiovascular translational research · 2010Article
- Decellularization of tumours: A new frontier in tissue engineering.Journal of tissue engineeringReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Xenotransplantation was proposed a long time ago as a possible solution to the world-wide shortage of human organs. For years, researchers in this field have almost exclusively directed their efforts towards combating the immunological barrier that precluded long-term xenograft survival. Studies have been conducted in both small and large animal models and the most relevant results have been obtained in pre-clincal studies, specifically those utilising the pig-to-nonhuman primate combination. In this context, a better understanding of the immunological mechanisms underlying the rejection of a xenograft have allowed the identification of specific targets of intervention that have resulted in considerable improvements in survival of porcine organs or cells in nonhuman primates. However it has also become apparent that if xenotransplantation has to enter the clinical arena, a multidisciplinary approach will be needed to comprehensively tackle the different issues related to the use of a xenograft to cure human disease.In this regard, the safety, ethics and regulatory aspects of xenotransplantation are currently being aggressively addressed to enable the initiation of xenotransplantation with a favourable risk/benefit ratio.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.