SynthesisAlzheimer disease and associated disorders
Missed and delayed diagnosis of dementia in primary care: prevalence and contributing factors.
Synthesis in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02420756 (Imaging Dementia-Evidence for Amyloid Scanning), which is not on this map. Cited by 513 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Imaging Dementia-Evidence for Amyloid Scanning (IDEAS) Study: A Coverage With Evidence Development Longitudinal Cohort Study
Who cites it
513 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- What Do We Know About Hospice Enrollment for Nursing Home Residents with Cognitive Disabilities? A Systematic Review.Journal of palliative medicine · 2026Pooled it
- Association of frailty and mortality risk in community-dwelling older adults: a systematic review and meta-analysis of 59 international prospective cohort studies.BMC public health · 2026Pooled it
- Associations between plasma beta amyloid and cognitive decline: A systematic review and meta-analysis.Narra J · 2025Pooled it
- Alzheimer's Association clinical practice guideline for the Diagnostic Evaluation, Testing, Counseling, and Disclosure of Suspected Alzheimer's Disease and Related Disorders (DETeCD-ADRD): Executive summary of recommendations for primary care.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Guideline
- Live Hospice Discharge of Individuals with Cognitive Disabilities: A Systematic Review.Journal of the American Medical Directors Association · 2025Pooled it
- Association between blood-based protein biomarkers and brain MRI in the Alzheimer's disease continuum: a systematic review.Journal of neurology · 2024Pooled it
- Cost-effectiveness of 5-Cog paradigm for individuals with cognitive concerns in primary care.Public health · 2025Trial
- Hyperspectral retinal imaging to detect Alzheimer's disease in a memory clinic setting.Alzheimer's research & therapy · 2025Trial
- Assessing Advance Care Planning Fidelity within the Context of Cognitive Impairment: The SHARE Trial.Journal of pain and symptom management · 2024Trial
- The AHEPA EEG benchmark: setting the standard for machine learning in dementia diagnosis, a scoping review.Cognitive neurodynamics · 2026Article
- Associations of Individual- and Neighborhood-Level Factors with Racial and Ethnic Disparities in Timely Dementia Diagnosis.Journal of general internal medicine · 2026Observational
- The path to treating multiple-etiology dementia: Combining vascular risk control and disease-modifying neurodegenerative therapies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- Article
- Agentic AI for scaling diagnosis and care in neurodegenerative disease.Nature aging · 2026Review
- Classification accuracies of plasma ptau217 vs. ptau217/Aβ1-42 for brain Aβ pathology in cognitively normal older adults.GeroScience · 2026Observational
- Recent advances in Alzheimer's disease: From molecular mechanisms to therapeutic strategies.Cell · 2026Review
- Real-Time Smartphone Monitoring Assessments as a Cognitive Biomarker of Alzheimer Disease: Protocol for a Development Study.JMIR research protocols · 2026Article
- Medical Challenges in Caring for Older Adults With Type 2 Diabetes and Dementia: A Qualitative Interview Study Using SCAT to Compare Primary Care Physicians and Diabetes Specialists in Japan.Journal of general and family medicine · 2026Article
- Increased dementia diagnosis and workup in primary care with a bilingual screening tool integrated in the electronic health record.Journal of Alzheimer's disease : JAD · 2026Article
- The role of phospho-ubiquitin in mitochondrial health and diseases.The Journal of biological chemistry · 2026Review
453 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Dementia is a growing public health problem for which early detection may be beneficial. Currently, the diagnosis of dementia in primary care is dependent mostly on clinical suspicion on the basis of patient symptoms or caregivers' concerns and is prone to be missed or delayed. We conducted a systematic review of the literature to ascertain the prevalence and contributing factors for missed and delayed dementia diagnoses in primary care. Prevalence of missed and delayed diagnosis was estimated by abstracting quantitative data from studies of diagnostic sensitivity among primary care providers. Possible predictors and contributory factors were determined from the text of quantitative and qualitative studies of patient, caregiver, provider, and system-related barriers. Overall estimates of diagnostic sensitivity varied among studies and seemed to be in part a function of dementia severity, degree of patient impairment, dementia subtype, and frequency of patient-provider contact. Major contributory factors included problems with attitudes and patient-provider communication, educational deficits, and system resource constraints. The true prevalence of missed and delayed diagnoses of dementia is unknown but seems to be high. Until the case for dementia screening becomes more compelling, efforts to promote timely detection should focus on removing barriers to diagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.