Trial reportBMJ (Clinical research ed.)2009
Recurrence up to 3.5 years after antibiotic treatment of acute otitis media in very young Dutch children: survey of trial participants.
Trial report in BMJ (Clinical research ed.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 5 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Pooled it
- Antibiotic treatment to prevent pediatric acute otitis media infectious complications: A meta-analysis.PloS one · 2024Pooled it
- Antibiotics for acute otitis media in children.The Cochrane database of systematic reviews · 2023Pooled it
- Antibiotics for acute otitis media in children.The Cochrane database of systematic reviews · 2015Pooled it
- Acute infective conjunctivitis in primary care: who needs antibiotics? An individual patient data meta-analysis.The British journal of general practice : the journal of the Royal College of General Practitioners · 2011Pooled it
- The evidence for applying Streptococcus salivarius 24SMB by nasal spray for preventing recurrent acute otitis media.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- Streptococcus salivarius by nasal spray for recurrent otitis: how good is the evidence?European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- Antibiotic Treatment for First Episode of Acute Otitis Media Is Not Associated with Future Recurrences.PloS one · 2016Article
- Parents' beliefs and knowledge about the management of acute otitis media: a qualitative study.BMC family practice · 2015Article
- Antibiotic Use in Children with Acute Respiratory or Ear Infections: Prospective Observational Comparison of Anthroposophic and Conventional Treatment under Routine Primary Care Conditions.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Beta- lactam antibiotics stimulate biofilm formation in non-typeable haemophilus influenzae by up-regulating carbohydrate metabolism.PloS one · 2014Article
- Article
- Natural history, definitions, risk factors and burden of otitis media.The Medical journal of Australia · 2009Review
Corrections and comments
- Commented on by
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the long term effects of antibiotic treatment for acute otitis media in young children.
designProspective three year follow-up study within the framework of a primary care based, double blind, randomised, placebo controlled trial.
setting53 general practices in the Netherlands.
participants168 children aged 6 months to 2 years with acute otitis media.
interventionsAmoxicillin 40 mg/kg/day in three doses compared with placebo.
main outcome measuresRecurrence of acute otitis media; referral to secondary care; ear, nose, and throat surgery.
resultsAcute otitis media recurred in 63% (47/75) of children in the amoxicillin group and in 43% (37/86) of the placebo group (risk difference 20%, 95% confidence interval 5% to 35%); 30% (24/78 amoxicillin; 27/89 placebo) of children in both groups were referred to secondary care, and 21% (16/78) of the amoxicillin group compared with 30% (27/90) of the placebo group had ear, nose, and throat surgery (risk difference -9%, -23% to 4%).
conclusionRecurrent acute otitis media occurred more often in the children originally treated with amoxicillin. This is another argument for judicious use of antibiotics in children with acute otitis media. Trial registration Netherlands Trial Register NTR1426.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.