ArticleJournal of the American Medical Informatics Association : JAMIA
The Shared Health Research Information Network (SHRINE): a prototype federated query tool for clinical data repositories.
Article in Journal of the American Medical Informatics Association : JAMIA. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 172 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
172 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Hybrid Architecture (CO-CONNECT) to Facilitate Rapid Discovery and Access to Data Across the United Kingdom in Response to the COVID-19 Pandemic: Development Study.Journal of medical Internet research · 2022Pooled it
- An autism case history to review the systematic analysis of large-scale data to refine the diagnosis and treatment of neuropsychiatric disorders.Biological psychiatry · 2015Pooled it
- Estimating the incidence and risk factors of postpartum hemorrhage from the national ENACT network.npj health systems · 2026Article
- Article
- Anonymization, accountability, and access: legal dimensions of health data sharing in federated networks. Perspectives from empirical study.Frontiers in digital health · 2026Article
- Federated causal discovery in medicine: trends, opportunities, and challenges.Frontiers in digital health · 2026Article
- Estimating the incidence and risk factors of postpartum hemorrhage from the national ENACT network.Research square · 2025Article
- Liability threshold model-based disease risk prediction based on electronic health record phenotypes.Nature genetics · 2025Article
- Implementation report on pioneering federated data access for the German National Emergency Department Data Registry.NPJ digital medicine · 2025Article
- The Challenges and Lessons Learned Building a New UK Infrastructure for Finding and Accessing Population-Wide COVID-19 Data for Research and Public Health Analysis: The CO-CONNECT Project.Journal of medical Internet research · 2024Article
- Economics and Equity of Large Language Models: Health Care Perspective.Journal of medical Internet research · 2024Article
- Bridging Data Models in Health Care With a Novel Intermediate Query Format for Feasibility Queries: Mixed Methods Study.JMIR medical informatics · 2024Article
- Towards cross-application model-agnostic federated cohort discovery.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- Trends in Postpartum Hemorrhage Prevalence and Comorbidity Burden: Insights from the ENACT Network Aggregated Electronic Health Record Data.Research square · 2024Article
- Cumulus: a federated electronic health record-based learning system powered by Fast Healthcare Interoperability Resources and artificial intelligence.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- GEN-RWD Sandbox: bridging the gap between hospital data privacy and external research insights with distributed analytics.BMC medical informatics and decision making · 2024Article
- Cumulus: A federated EHR-based learning system powered by FHIR and AI.medRxiv : the preprint server for health sciences · 2024Article
- Biomedical Big Data Technologies, Applications, and Challenges for Precision Medicine: A Review.Global challenges (Hoboken, NJ) · 2024Review
- A broadly applicable approach to enrich electronic-health-record cohorts by identifying patients with complete data: a multisite evaluation.Journal of the American Medical Informatics Association : JAMIA · 2023Article
- An ontology-based approach for harmonization and cross-cohort query of Alzheimer's disease data resources.BMC medical informatics and decision making · 2023Article
112 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The authors developed a prototype Shared Health Research Information Network (SHRINE) to identify the technical, regulatory, and political challenges of creating a federated query tool for clinical data repositories. Separate Institutional Review Boards (IRBs) at Harvard's three largest affiliated health centers approved use of their data, and the Harvard Medical School IRB approved building a Query Aggregator Interface that can simultaneously send queries to each hospital and display aggregate counts of the number of matching patients. Our experience creating three local repositories using the open source Informatics for Integrating Biology and the Bedside (i2b2) platform can be used as a road map for other institutions. The authors are actively working with the IRBs and regulatory groups to develop procedures that will ultimately allow investigators to obtain identified patient data and biomaterials through SHRINE. This will guide us in creating a future technical architecture that is scalable to a national level, compliant with ethical guidelines, and protective of the interests of the participating hospitals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.