ArticleThe Plant cell2009
The maize transcription factor KNOTTED1 directly regulates the gibberellin catabolism gene ga2ox1.
Article in The Plant cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers.
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158 citing papers in PubMed, 300 citations in OpenAlex.
- Maize ZmMYB59 inhibits post-germinative shoot and root elongation through ZmGA2ox3/10-mediated gibberellin catabolism.The New phytologist · 2026Article
- The CmABI5-CmKN1 module regulates seasonal growth and flowering in response to chilling in chrysanthemum.The New phytologist · 2026Article
- A single-nucleus atlas of ligular region uncovers brassinosteroid-driven cell fate transitions controlling leaf angle in maize.Nature communications · 2026Article
- Insights into Candidate Pathways Associated with Multi-Pistil Formation in Chinese Chestnut (Biology · 2026Article
- Genome-Wide Analysis of thePlants (Basel, Switzerland) · 2026Article
- Dynamic and cell-type specific transcriptional reprogramming underlies the floral transition in the maize shoot apical meristem.Genome biology · 2026Article
- Stem cell regulation: conserved pluripotency, transcriptional, and metabolic networks in animals and plants.Frontiers in cell and developmental biology · 2026Review
- Systematic mutagenesis reveals dominant-minor paralog configurations in the riceFrontiers in plant science · 2026Article
- Novel genome editing approaches to manipulate apical meristem activity for crop yield.Frontiers in plant science · 2026Review
- "Bud to bloom"-hormonal coordination in floral initiation.Plant biology (Stuttgart, Germany) · 2025Review
- Article
- Analysis of the IPT gene family reveals the critical role of the JrERF113-JrIPT1 module in cold resistance of walnut (Juglans regia).BMC plant biology · 2025Article
- Phytochrome B stabilizes the KNOX transcription factor BP/KNAT1 to promote light-initiated seed germination in Arabidopsis thaliana.Plant communications · 2025Article
- A multi-parent population approach to reveal the genetic basis of plant height in maize.BMC plant biology · 2025Article
- miR156-SPLs module regulates flowering and controls plant height by modulating gibberellin biosynthesis in citrus.Plant biotechnology journal · 2025Article
- Genome-Wide Association Analysis of Fresh Maize.International journal of molecular sciences · 2025Article
- Genome assembly and population genomic analysis reveal the genetic basis of popcorn evolution.Plant biotechnology journal · 2025Article
- Insights into the genomic divergence of maize heterotic groups in China.Journal of integrative plant biology · 2025Article
- Functional Characterization of KNOX and BELL Genes in Temperature-Responsive Floral Morphogenesis of Passion Fruit (Plants (Basel, Switzerland) · 2025Article
- Gibberellins: extending the Green Revolution.Journal of experimental botany · 2025Review
98 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
KNOTTED1 (KN1)-like homeobox (KNOX) transcription factors are involved in the establishment and maintenance of plant meristems; however, few direct targets of KNOX proteins have been recognized. Using a combination of double mutant analysis and biochemistry, we found that in maize (Zea mays), KN1 negatively modulates the accumulation of gibberellin (GA) through the control of ga2ox1, which codes for an enzyme that inactivates GA. The ga2ox1 mRNA level is elevated in immature leaves of dominant KNOX mutants and downregulated in reproductive meristems of the null allele kn1-e1. KN1 binds in vivo to an intron of ga2ox1 through a cis-regulatory element containing two TGAC motifs. VP16-KN1 activates transcription in planta from a chimeric promoter containing this binding site. The domains of expression of kn1 and ga2ox1 mRNAs overlap at the base of the shoot apical meristem and the base of newly initiated leaves, suggesting that KN1-mediated activation of ga2ox1 maintains a boundary between meristem cell identity and rapidly elongating cells of the shoot. The KN1 binding site is conserved in ga2ox1 genes of different grasses, suggesting that the local regulation of bioactive GA levels through KNOX proteins is a common theme in grasses.
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