Evidence map›Paper›PMID 19567516›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2009

The effect of vitamin D2 and vitamin D3 on intestinal calcium absorption in Nigerian children with rickets.

Tom D Thacher, Michael O Obadofin, Kimberly O O'Brien, Steven A Abrams

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01079923 (Pilot Pharmacokinetic Study of Daily Versus Monthly High-Dose Cholecalciferol Supplementation), which is not on this map. Cited by 25 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 4 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01079923 nacompletednot on this mapstarted 2010, after this paper: background citation

Pilot Pharmacokinetic Study of Daily Versus Monthly High-Dose Cholecalciferol Supplementation

TypeinterventionalSponsorMayo ClinicRan2010 to 2010Enrolled40ConditionsHealthy VolunteersArmsSingle High Dose Cholecalciferol, Daily Dose Cholecalciferol
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 73 citations in OpenAlex.

  1. Pooled it
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  9. No change in calcium absorption in adult Pakistani population before and after vitamin D administration using strontium as surrogate.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013
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  11. Review
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  19. Hormonal and dietary influences on true fractional calcium absorption in women: role of obesity.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Tom D ThacherDepartment of Family Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA. thacher.thomas@mayo.edu
Michael O Obadofin
Kimberly O O'Brien
Steven A Abrams
Children's Nutrition Research Center at Baylor College of Medicine · USCornell University · USJos University Teaching Hospital · NGMayo Clinic · US

Funding

Dietary Factors Affecting Calcium and Zinc AbsorptionR03TW006428 · FIC · BAYLOR COLLEGE OF MEDICINE · PI ABRAMS, STEVEN A · 2004 to 2006
$122k
FIC NIH HHS R03 TW006428
6 · The paper itself

Abstract

contextChildren with calcium-deficiency rickets have high 1,25-dihydroxyvitamin D values.

objectiveThe objective of the study was to determine whether vitamin D increased calcium absorption.

designThis was an experimental study.

settingThe study was conducted at a teaching hospital.

participantsParticipants included 17 children with nutritional rickets.

interventionThe participants were randomized to 1.25 mg oral vitamin D(3) (n = 8) or vitamin D(2) (n = 9).

main outcome measureFractional calcium absorption 3 da after vitamin D administration was measured.

resultsMean baseline 25-hydroxyvitamin D concentrations were 20 ng/ml (range 5-31 ng/ml). The increase in 25-hydroxyvitamin D was equivalent after vitamin D(3) (29 +/- 10 ng/ml) or vitamin D(2) (29 +/- 17 ng/ml). Mean 1,25-dihydroxyvitamin D values increased from 143 +/- 76 pg/ml to 243 +/- 102 pg/ml (P = 0.001), and the increase in 1,25-dihydroxyvitamin D did not differ between vitamin D(2) and vitamin D(3) (107 +/- 110 and 91 +/- 102 ng/ml, respectively). The increment in 1,25-dihydroxyvitamin D was explained almost entirely by the baseline 25-hydroxyvitamin D concentration (r(2) = 0.72; P < 0.001). Mean fractional calcium absorption did not differ before (52.6 +/- 21.4%) or after (53.2 +/- 23.5%) vitamin D, and effects of vitamin D(2) and vitamin D(3) on calcium absorption were not significantly different. Fractional calcium absorption was not closely related to concentrations of 25-hydroxyvitamin D (r = 0.01, P = 0.93) or 1,25-dihydroxyvitamin D (r = 0.21, P = 0.24). The effect of vitamin D on calcium absorption did not vary with baseline 25-hydroxyvitamin D values or with the absolute increase in 25-hydroxyvitamin D or 1,25-dihydroxyvitamin D values.

conclusionsDespite similar increases in 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D with vitamin D(2) or vitamin D(3), fractional calcium absorption did not increase, indicating that rickets in Nigerian children is not primarily due to vitamin D-deficient calcium malabsorption.

Indexed as

Intestinal AbsorptionCalciumChildChild, PreschoolCholecalciferolErgocalciferolsFemaleHumansMaleNigeriaRicketsVitamin D1,25-dihydroxyvitamin D25-hydroxyvitamin DCalciumCholecalciferolErgocalciferolsVitamin D

Identifiers

PMID19567516
PMCPMC2741710
OpenAlexW2100992699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.