ArticleMolecular pain2009
Excitatory neurotransmitters in brain regions in interictal migraine patients.
Article in Molecular pain, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 92 citations in OpenAlex.
- Metabolomic insights into migraine: mechanisms and biomarkers from in vivo and clinical studies.Metabolic brain disease · 2026Review
- Metabolic abnormalities in the insula of patients with interictal migraine without aura: a prospective cross-sectional study.Quantitative imaging in medicine and surgery · 2025Article
- Alterations in metabolites in the anterior cingulate cortex and thalamus and their associations with pain and empathy in patients with chronic mild pain: a preliminary study.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- Excitation-Inhibition Imbalance in Migraine: From Neurotransmitters to Brain Oscillations.International journal of molecular sciences · 2023Review
- Exploring Novel Therapeutic Targets in the Common Pathogenic Factors in Migraine and Neuropathic Pain.International journal of molecular sciences · 2023Review
- Decreased Brain GABA Levels in Patients with Migraine Without Aura: An Exploratory Proton Magnetic Resonance Spectroscopy Study.Neuroscience · 2022Article
- Mitochondrial function and oxidative stress markers in higher-frequency episodic migraine.Scientific reports · 2021Article
- Interictal pontine metabolism in migraine without aura patients: A 3 Tesla proton magnetic resonance spectroscopy study.NeuroImage. Clinical · 2021Article
- Neurochemical metabolite alterations of the occipital lobe in migraine without aura by proton magnetic resonance spectroscopy.The neuroradiology journal · 2020Article
- The metabolic face of migraine - from pathophysiology to treatment.Nature reviews. Neurology · 2019Review
- Alterations in Regional Homogeneity Assessed by fMRI in Patients with Migraine Without Aura.Journal of medical systems · 2019Article
- Article
- Sensory Modulation Disorder (SMD) and Pain: A New Perspective.Frontiers in integrative neuroscience · 2019Article
- Metabolic assessment of a migraine model using relaxation-enhancedMagnetic resonance in medicine · 2018Article
- Migrainomics - identifying brain and genetic markers of migraine.Nature reviews. Neurology · 2017Review
- In child and adult migraineurs the somatosensory cortex stands out … again: An arterial spin labeling investigation.Human brain mapping · 2017Article
- High Frequency Migraine Is Associated with Lower Acute Pain Sensitivity and Abnormal Insula Activity Related to Migraine Pain Intensity, Attack Frequency, and Pain Catastrophizing.Frontiers in human neuroscience · 2016Article
- A 'complex' of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients.NeuroImage. Clinical · 2016Article
- Biochemistry of primary headaches: role of tyrosine and tryptophan metabolism.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015Review
- Primary Somatosensory Cortices Contain Altered Patterns of Regional Cerebral Blood Flow in the Interictal Phase of Migraine.PloS one · 2015Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveTo examine biochemical differences in the anterior cingulate cortex (ACC) and insula during the interictal phase of migraine patients. We hypothesized that there may be differences in levels of excitatory amino acid neurotransmitters and/or their derivatives in migraine group based on their increased sensitivity to pain.
methods2D J-resolved proton magnetic resonance spectroscopy (1H-MRS) data were acquired at 4.0 Tesla (T) from the ACC and insula in 10 migraine patients (7 women, 3 men, age 43 +/- 11 years) and 8 age gender matched controls (7 women, 3 men, age 41 +/- 9 years).
resultsStandard statistical analyses including analysis of variance (ANOVA) showed no significant metabolite differences between the two subject cohorts in the ACC nor the insula. However, linear discriminant analysis (LDA) introduced a clear separation between subject cohorts based on N-acetyl aspartylglutamate (NAAG) and glutamine (Gln) in the ACC and insula.
conclusionThese results are consistent with glutamatergic abnormalities in the ACC and insula in migraine patients during their interictal period compared to healthy controls. An alteration in excitatory amino acid neurotransmitters and their derivatives may be a contributing factor for migraineurs for a decrease in sensitivity for migraine or a consequence of the chronic migraine state. Such findings, if extrapolated to other regions of the brain would offer new opportunities to modulate central system as interictal or preemptive medications in these patients.
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