Evidence map›Paper›PMID 19566916›Full record

ArticleGenome medicine2009

Translational bioinformatics applications in genome medicine.

Atul J Butte

Abstract readEditorial
In one paragraph

Article in Genome medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Biomedical informatics and translational medicine.Journal of translational medicine · 2010
    Review
  6. A framework for comparing phenotype annotations of orthologous genes.Studies in health technology and informatics · 2010
    Article
  7. Translational bioinformatics: linking knowledge across biological and clinical realms.Journal of the American Medical Informatics Association : JAMIA
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Atul J ButteStanford Center for Biomedical Informatics, Department of Medicine and Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA, and Lucile Packard Children's Hospital, Palo Alto, CA 94304, USA. abutte@stanford.edu.

Funding

Repositioning drugs for the treatment of small cell lung cancerR01GM079719 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BUTTE, ATUL J · 2006 to 2015
$4.4M
Integrating Microarray and Proteomic Data by Ontology-based AnnotationR01LM009719 · NLM · STANFORD UNIVERSITY · PI BUTTE, ATUL J · 2008 to 2011
$1.1M
NIGMS NIH HHS R01 GM079719NLM NIH HHS R01 LM009719
6 · The paper itself

Abstract

Although investigators using methodologies in bioinformatics have always been useful in genomic experimentation in analytic, engineering, and infrastructure support roles, only recently have bioinformaticians been able to have a primary scientific role in asking and answering questions on human health and disease. Here, I argue that this shift in role towards asking questions in medicine is now the next step needed for the field of bioinformatics. I outline four reasons why bioinformaticians are newly enabled to drive the questions in primary medical discovery: public availability of data, intersection of data across experiments, commoditization of methods, and streamlined validation. I also list four recommendations for bioinformaticians wishing to get more involved in translational research.

Identifiers

PMID19566916
PMCPMC2703873

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.