ArticleThe Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association2009
Exceptional brain aging in a rural population-based cohort.
Article in The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- The effects of noncoding aquaporin-4 single-nucleotide polymorphisms on cognition and functional progression of Alzheimer's disease.Alzheimer's & dementia (New York, N. Y.) · 2017Article
- Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2017Article
- Risk of incident clinical diagnosis of Alzheimer's disease-type dementia attributable to pathology-confirmed vascular disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2017Article
- Alzheimer's disease neuropathologic change, Lewy body disease, and vascular brain injury in clinic- and community-based samples.Neurobiology of aging · 2017Article
- Outcomes after diagnosis of mild cognitive impairment in a large autopsy series.Annals of neurology · 2017Article
- Multi-state models and missing covariate data: Expectation-Maximization algorithm for likelihood estimation.Biostatistics & epidemiology · 2017Article
- Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2016Article
- Article
- The Statistical Modeling of Aging and Risk of Transition Project: Data Collection and Harmonization Across 11 Longitudinal Cohort Studies of Aging, Cognition, and Dementia.Observational studies · 2015Article
- Reduced prevalence of cognitive impairment in families with exceptional longevity.JAMA neurology · 2013Article
- Dementia in the oldest old: a multi-factorial and growing public health issue.Alzheimer's research & therapy · 2013Review
- The Relation between Inflammation and Neuropsychological Test Performance.International journal of Alzheimer's disease · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
contextThe 2000 US Census identified 50,454 Americans over the age of 100. Increased longevity is only of benefit if accompanied by maintenance of independence and quality of life. Little is known about the prevalence of dementia and other disabling conditions among rural centenarians although this information is important to clinicians caring for them. PURPOSE: To determine the prevalence of disabling conditions, including cognitive impairment, among the very elderly in a rural setting to guide clinicians in their care.
methodsWe performed a population-based cohort study of all residents 97 years and older in the Klamath Basin, a rural region in southern Oregon. The prevalence of disabling conditions was determined by in-person examination.
findingsAbout 100% of the target sample was identified. Of the eligible 67 individuals > or =97 years old, 31 were evaluated in-person. The prevalence of dementia (probable or possible Alzheimer's disease or vascular dementia) was 61.3% (95% CI: 43.8, 76.2), mild cognitive impairment was 29.0% (95% CI: 16.1, 46.6), and no dementia was 9.7% (95% CI: 3.4, 25.0). Parkinsonism and the APOEe4 allele were rare. Systemic vascular disease was almost universally present.
conclusionsWhile cognitive impairment was nearly universal in this rural population of very elderly persons, almost 40% had not progressed to full dementia. Determining risk factors for dementia in this population can identify strategies to prevent progression to dementia among younger elderly populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.