ArticleThe Journal of chemical physics2009
Positive feedback regulation results in spatial clustering and fast spreading of active signaling molecules on a cell membrane.
Article in The Journal of chemical physics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A computational rule-based model of MAPK/ERK system regulation.Scientific reports · 2026Article
- Compartmental exchange regulates steady states and stochastic switching of a phosphorylation network.Biophysical journal · 2024Article
- An optimal control approach for enhancing natural killer cells' secretion of cytolytic molecules.APL bioengineering · 2020Article
- Cellular self-organization: generating order from the abyss.Molecular biology of the cell · 2020Review
- Differential mast cell outcomes are sensitive to FcεRI-Syk binding kinetics.Molecular biology of the cell · 2017Article
- Relaxation oscillations and hierarchy of feedbacks in MAPK signaling.Scientific reports · 2017Article
- Cooperative Clustering Digitizes Biochemical Signaling and Enhances its Fidelity.Biophysical journal · 2016Article
- Spatio-temporal model of endogenous ROS and raft-dependent WNT/beta-catenin signaling driving cell fate commitment in human neural progenitor cells.PLoS computational biology · 2015Article
- Stochastic transitions in a bistable reaction system on the membrane.Journal of the Royal Society, Interface · 2013Article
- Membrane clustering and the role of rebinding in biochemical signaling.Biophysical journal · 2012Article
- A bistable model of cell polarity.PloS one · 2012Article
- A density-dependent switch drives stochastic clustering and polarization of signaling molecules.PLoS computational biology · 2011Article
- B cell activation triggered by the formation of the small receptor cluster: a computational study.PLoS computational biology · 2011Article
- Activation or tolerance of natural killer cells is modulated by ligand quality in a nonmonotonic manner.Biophysical journal · 2010Article
- Understanding the structure and function of the immunological synapse.Cold Spring Harbor perspectives in biology · 2010Review
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3 authors.
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Abstract
Positive feedback regulation is ubiquitous in cell signaling networks, often leading to binary outcomes in response to graded stimuli. However, the role of such feedbacks in clustering, and in spatial spreading of activated molecules, has come to be appreciated only recently. We focus on the latter, using a simple model developed in the context of Ras activation with competing negative and positive feedback mechanisms. We find that positive feedback, in the presence of slow diffusion, results in clustering of activated molecules on the plasma membrane, and rapid spatial spreading as the front of the cluster propagates with a constant velocity (dependent on the feedback strength). The advancing fronts of the clusters of the activated species are rough, with scaling consistent with the Kardar-Parisi-Zhang equation in one dimension. Our minimal model is general enough to describe signal transduction in a wide variety of biological networks where activity in the membrane-proximal region is subject to feedback regulation.
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