ArticleThe Journal of comparative neurology2009
Grueneberg ganglion olfactory subsystem employs a cGMP signaling pathway.
Article in The Journal of comparative neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 63 citations in OpenAlex.
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- Epigenetic programming of stochastic olfactory receptor choice.Genesis (New York, N.Y. : 2000) · 2024Review
- Identification of putative ingestion-related olfactory receptor genes in the Chinese mitten crab (Eriocheir japonica sinensis).Genes & genomics · 2021Article
- The Grueneberg ganglion: signal transduction and coding in an olfactory and thermosensory organ involved in the detection of alarm pheromones and predator-secreted kairomones.Cell and tissue research · 2021Review
- Olfactory subsystems associated with the necklace glomeruli in rodents.Cell and tissue research · 2021Review
- Renewal and Differentiation of GCD Necklace Olfactory Sensory Neurons.Chemical senses · 2020Article
- Gli3 Regulates Vomeronasal Neurogenesis, Olfactory Ensheathing Cell Formation, and GnRH-1 Neuronal Migration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Alarm pheromone and kairomone detection via bitter taste receptors in the mouse Grueneberg ganglion.BMC biology · 2018Article
- Guanylyl cyclase-G is an alarm pheromone receptor in mice.The EMBO journal · 2018Article
- P/Q Type Calcium Channel Cav2.1 Defines a Unique Subset of Glomeruli in the Mouse Olfactory Bulb.Frontiers in cellular neuroscience · 2018Article
- Nonproliferative and Proliferative Lesions of the Ratand Mouse Special Sense Organs(Ocular [eye and glands], Olfactory and Otic).Journal of toxicologic pathology · 2018Review
- Cell type-dependent axonal localization of translational regulators and mRNA in mouse peripheral olfactory neurons.The Journal of comparative neurology · 2017Article
- Grueneberg Glomeruli in the Olfactory Bulb are Activated by Odorants and Cool Temperature.Cellular and molecular neurobiology · 2017Article
- Cell- and region-specific expression of depression-related protein p11 (S100a10) in the brain.The Journal of comparative neurology · 2017Article
- Integrating temperature with odor processing in the olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Innate Predator Odor Aversion Driven by Parallel Olfactory Subsystems that Converge in the Ventromedial Hypothalamus.Current biology : CB · 2015Article
- Receptor guanylyl cyclase-G is a novel thermosensory protein activated by cool temperatures.The EMBO journal · 2015Article
- Identification of pyridine analogs as new predator-derived kairomones.Frontiers in neuroscience · 2015Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The mammalian olfactory sense employs several olfactory subsystems situated at characteristic locations in the nasal cavity to detect and report on different classes of odors. These olfactory subsystems use different neuronal signal transduction pathways, receptor expression repertoires, and axonal projection targets. The Grueneberg ganglion (GG) is a newly appreciated olfactory subsystem with receptor neurons located just inside of the nostrils that project axons to a unique domain of interconnected glomeruli in the caudal olfactory bulb. It is not well understood how the GG relates to other olfactory subsystems in contributing to the olfactory sense. Furthermore, the range of chemoreceptors and the signal transduction cascade utilized by the GG have remained mysterious. To resolve these unknowns, we explored the molecular relationship between the GG and the GC-D neurons, another olfactory subsystem that innervates similarly interconnected glomeruli in the same bulbar region. We found that mouse GG neurons express the cGMP-associated signaling proteins phosphodiesterase 2a, cGMP-dependent kinase II, and cyclic nucleotide gated channel subunit A3 coupled to a chemoreceptor repertoire of cilia-localized particulate guanylyl cyclases (pGC-G and pGC-A). The primary cGMP signaling pathway of the GG is shared with the GC-D neurons, unifying their target glomeruli as a unique center of olfactory cGMP signal transduction. However, the distinct chemoreceptor repertoire in the GG suggests that the GG is an independent olfactory subsystem. This subsystem is well suited to detect a unique set of odors and to mediate behaviors that remained intact in previous olfactory perturbations.
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