ArticleNeurocritical care2009
Diagnosing brain death by CT perfusion and multislice CT angiography.
Article in Neurocritical care, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02045407 (Computed Tomography Angiography Accuracy in Brain Death Diagnosis), which is not on this map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Computed Tomography Angiography Accuracy in Brain Death Diagnosis
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Guidelines for the assessment and acceptance of potential brain-dead organ donors.Revista Brasileira de terapia intensiva · 2016Guideline
- Computed tomography angiography in the diagnosis of brain death: a systematic review and meta-analysis.Neurocritical care · 2014Pooled it
- Computed tomography (CT) angiography for confirmation of the clinical diagnosis of brain death.The Cochrane database of systematic reviews · 2014Pooled it
- A ten-year retrospective analysis of decompressive craniectomy or craniotomy after severe brain injury and its implications for donation after brain death.Scientific reports · 2024Article
- Role of Clinical and Multimodality Neuroimaging in the Evaluation of Brain Death/Death by Neurologic Criteria and Recent Highlights from 2023 Updated Guidelines.Diagnostics (Basel, Switzerland) · 2024Review
- Measuring brain perfusion by CT or MR as ancillary tests for diagnosis of brain death: a systematic review and meta-analysis.BJR open · 2024Article
- Pictorial Review on Imaging Findings in Cerebral CTP in Patients with Acute Stroke and Its Mimics: A Primer for General Radiologists.Diagnostics (Basel, Switzerland) · 2023Review
- Brain death in a vaccinated patient with COVID-19 infection.Clinical imaging · 2022Article
- Implementation of Computed Tomography Angiography (CTA) and Computed Tomography Perfusion (CTP) in Polish Guidelines for Determination of Cerebral Circulatory Arrest (CCA) during Brain Death/Death by Neurological Criteria (BD/DNC) Diagnosis Procedure.Journal of clinical medicine · 2021Article
- Assessment of Cerebral Circulatory Arrest via CT Angiography and CT Perfusion in Brain Death Confirmation.Korean journal of radiology · 2021Article
- Utility of brain parenchyma density measurement and computed tomography perfusion imaging in predicting brain death.Polish journal of radiology · 2020Article
- The observation period after clinical brain death diagnosis according to ancillary tests: differences between supratentorial and infratentorial brain injury.Journal of neurology · 2019Observational
- Article
- Impact of Skull Defects on the Role of CTA for Brain Death Confirmation.AJNR. American journal of neuroradiology · 2019Observational
- The role of cervical color Doppler ultrasound in the diagnosis of brain death.Neuroradiology · 2019Article
- The Role of Neuroimaging in the Determination of Brain Death.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2018Article
- Rapid Brain Death following Cardiac Arrest without Intracranial Pressure Rise and Cerebral Circulation Arrest.Case reports in critical care · 2018Article
- Feasibility of dual-low scheme combined with iterative reconstruction technique in acute cerebral infarction volume CT whole brain perfusion imaging.Experimental and therapeutic medicine · 2017Article
- Revised CT angiography venous score with consideration of infratentorial circulation value for diagnosing brain death.Annals of intensive care · 2016Article
- [Angiographic procedures for determination of cessation of cerebral circulation].Der Nervenarzt · 2016Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlthough the diagnosis of brain death (BD) is usually based on clinical criteria, in sedated patients, ancillary techniques are needed. This study was designed to assess the accuracy of cerebral multislice computed tomographic angiography (CTA) and CT perfusion (CTP) in diagnosing BD.
methodsProspective observational study in 27 BD patients.
resultsAll patients were diagnosed as BD based on clinical and electroencephalogram findings. After BD diagnosis, CTP was performed followed by 64-detector multislice CTA from the aortic arch to the vertex. Images were reconstructed from 0.5 mm sections. In 24 patients, a lack of cerebral blood flow (CBF) was detected by CTP, and CTA revealed luminal narrowing of the internal carotid artery in the neck and absence of anterior and posterior intracranial circulation (sensitivity 89%). CTA detected CBF exclusively in extracranial portions of the internal carotid and vertebral arteries. Two patients with anoxic brain injury and decompressive craniectomy showed CBF in the CTA such that the CTP results were considered false negatives, given BD had been confirmed by clinical and EEG findings, along with evoked potentials. In one clinically BD patient, in whom an alpha rhythm was detected in the electroencephalogram, CBF was only observed in the intracranial internal carotid with no posterior circulation noted. This patient was therefore considered exclusively brain stem dead.
conclusionsThe radiological protocol used shows a high sensitivity and excellent specificity for detecting the cerebral circulatory arrest that accompanies BD. As a rapid, non-invasive, and widely available technique it is a promising alternative to conventional 4-vessel angiography.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.