Trial reportOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2010
Population screening for osteoporosis risk: a randomised control trial of medication use and fracture risk.
Trial report in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Recommendations on screening for primary prevention of fragility fractures.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023Guideline
- Pooled it
- Fracture prevention by screening for high fracture risk: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Pooled it
- The impact of pharmacist interventions on osteoporosis management: a systematic review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2011Pooled it
- Long-term cost-effectiveness of screening for fracture risk in a UK primary care setting: the SCOOP study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Trial
- Effectiveness and cost-effectiveness of targeted and population screening for osteoporosis in women: scoping review.Health technology assessment (Winchester, England) · 2026Article
- Sex and age specific bone mineral density trends in Sri Lankan adults support the need for normative reference data.Frontiers in endocrinology · 2026Article
- Philippine Clinical Practice Guidelines for Periodic Health Examination: Screening for Musculoskeletal Disorders.Acta medica Philippina · 2026Article
- Application of Artificial Intelligence Methods on Osteoporosis Classification with Radiographs-A Systematic Review.Bioengineering (Basel, Switzerland) · 2024Review
- Opportunistic hand radiographs to screen for low forearm bone mineral density: a prospective and retrospective cohort study.BMC musculoskeletal disorders · 2024Article
- Article
- Population screening for fracture risk in postmenopausal women - a logical step in reducing the osteoporotic fracture burden?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- Is it time to consider population screening for fracture risk in postmenopausal women? A position paper from the International Osteoporosis Foundation Epidemiology/Quality of Life Working Group.Archives of osteoporosis · 2022Article
- BatchBMD as an Efficient and Accurate Dual-Energy X-ray Absorptiometry Report Generator.Diagnostics (Basel, Switzerland) · 2021Article
- Use of routine computed tomography scans for detecting osteoporosis in thoracolumbar vertebral bodies.Skeletal radiology · 2021Article
- The epidemiology of osteoporosis.British medical bulletin · 2020Review
- Toward a Mathematical Modeling of Diseases' Impact on Bone Remodeling: Technical Review.Frontiers in bioengineering and biotechnology · 2020Review
- Fracture prediction, imaging and screening in osteoporosis.Nature reviews. Endocrinology · 2019Review
- Aromatase inhibitors are associated with a higher fracture risk than tamoxifen: a systematic review and meta-analysis.Therapeutic advances in musculoskeletal disease · 2018Review
- Osteoporosis: A Review of Treatment Options.P & T : a peer-reviewed journal for formulary management · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledRandomised control trial of osteoporosis screening in 4,800 women aged 45-54 years was carried out. Screened group observed an increase of 7.9% in hormone replacement therapy (HRT) use (p < 0.001), 15% in other osteoporosis treatments (p < 0.001) and a 25.9% reduction in fracture risk compared with control. Screening for osteoporosis significantly increases treatment use and reduces fracture incidence.
introductionPopulation screening programmes can identify menopausal women with low bone mineral density (BMD) and elevated risk of future fracture but require to be proven effective by a randomised control trial.
methodsA total of 4,800 women, 45-54 years, were randomised in equal numbers to screening or no screening (control) groups. Following screening, those in the lowest quartile of BMD were advised to consider HRT. Nine years later, the effect of screening on the uptake of treatment and the incidence of fractures were assessed by postal questionnaire. Categorical differences were assessed using chi(2) test. Cox regression was used to assess hazard ratio (HR).
resultsOf the screened and the control groups, 52.4% vs 44.5%, respectively, reported taking HRT (p < 0.001). In addition, 36.6% of the screened vs 21.6% of the control groups reported the use of vitamin D, calcium, alendronate, etidronate or raloxifene (p < 0.001). In a per protocol analysis of verified incident fractures, a 25.9% reduction in risk of fractures (of any site) in the screened group was observed (HR = 0.741, 95% CI = 0.551-0.998 adjusted age, weight and height).
conclusionsScreening for osteoporosis as assessed by low bone density significantly increases the use of HRT and other treatments for osteoporosis and reduces fracture incidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.